Study On The Expression And Significance Of TGF-β1, VEGF And CD105 In Colorectal Adenocarcinoma

Objective: To study the effects of the expression of TGF-β1, VEGF and CD105 on carcinogenesis and progression in colorectal adenocarcinoma, in order to provide some valuable evidence for prognosis and biotherapy.Methods: The expression levels of TGF-β1, VEGF and CD105 were measured by S-P immunohistochemistry in 52 cases of colorectal adenocarcinoma and 10 cases of normal control. Their relationship relating with clinic-pathological features and survival was also analyzed.Results: (1) The expression ratios of TGF-pi in normal control and in colorectal adenocarcinoma were 30% and 78.8% respectively, showing significant difference (p<0.01). The TGF-β1 expression level in 52 cases of adenocarcinoma positively correlated with Dukes stages and metastasis of lymph nodes (p<0.01), while no significant difference was observed in sex, age, the location and the size of tumor and histological grade. (2) The expression ratios of VEGF in normal control and in colorectal adenocarcinoma were 20% and 73.08% respectively, showing significant difference (p<0.01). The expression level of VEGF in 52 cases of adenocarcinoma positively correlated with Dukes stages and metastasis of lymph nodes (p<0.01), while no significant difference was observed in sex, age, the location and the size of tumor and histological grade. (3) The mean MVD marked by CD105 in colorectal adenocarcinoma and in normal control was 11.27±1.55 and 1.30 ±0.70 respectively, showing significant difference (p<0.01). In 52 cases of adenocarcinoma, the mean MVD in Dukes stage C-D (17.86±2.07) was much high than in stage A-B(6.43±1.78)(p<0.01), and the mean...