Expression And Clinical Significance Of HIF-1α And VEGF In Human Gastric Carcinoma

Objective: To investigate the expression of hypoxia inducible factor- 1 alpha (HIF-1α) antigen and vascular endothelial growth factor (VEGF) protein in gastric carcinoma, and the relationship between their overexpression and the clinicopathologic parameters of gastric carcinoma.Methods: StreptAvidin-Biotin Complex (SABC) immunohistochemical method was used to detect the expression of HIF-1αantigen and VEGF protein in 55cases of gastric carcinoma, 12 cases chronic superficial gastritis, and 18 cases precancerous lesions.Results: (1) The expression of HIF-1αin chronic superficial gastritis was negative, but in precancerous lesions, the positive expression rate was 16.7%(3/18) and in gastric carcinoma was 69.1% (38/55), among the gastric carcinoma, negative expression rate was 30.9% (17/55), weak, moderate and strong positive expression rate was 32.7% (18/55), 20.0% (11/55) and 16.4% (9/55), respectively, which was significantly higher than that in precancerous lesions and chronic superficial gastritis. (2) The expression of HIF-1αwas statistically significantly associated with the depth of invasion (p<0.005),lymph node metastasis (p<0.005),TNM stage (p<0.05) and distant metastasis (p<0.01), but not associated with patients'age, gender, tumor location, Lauren type, tumor size and degree of differentiation. (3) The detected positive rate of VEGF protein varied as follows: 0.0%(0/13) in chronic superficial gastritis, 27.8%(5/18) in precancerous lesions, 61.8%(34/55) in gastric carcinoma, among which the negative expression rate was 38.2% (21/55), weak, moderate and strong positive expression rate was 29.1% (16/55), 18.1% (10/55) and 14.6% (8/55), respectively, which was significantly higher than that in precancerous lesions and...