Influence Of Microinflammation On The Curative Of Erythropoietin In Non-Dialysis CRF Patients

Objective: To investigate the influence of microinflammation on the curative effect of Erythropoietin in non-dialysis CRF patients.Methods: Serum IL-6 and TNF-a were measured with ELISA and CRP was measured with immunoturbidimetry in 130 non-dialysis CRF patients. All patients were not complicating with chronic or acute infection disease and hyper-parathyroidism, and all patients were not therapied with rhu-EPO before. Patients were divided into microinflammation group (Group A, n=41) and non-microinflamination group (Group B, n=89) according to the density of IL-6 , TNF-a and CRP. Serum Hb was measured after 3 months in all patients. At the same time 10 healthy blood donators were chosen as the healthy control group(Group C).All the data were counted and analyzed with the SPSS 10.0 software.Results: Before treatment the density of Hb of group A is (70 ± 26) g/L, and group B is (73 ± 25) g/L. After treatment with rhu-EPO , the density of Hb of group B increased faster. Increased Hb-level in group B ( (8. 36 ± 5. 86) g/L ) is higher than group A ((6.31 ± 4.14)g/L), it turns out an obvious difference in comparation with group A.Conclusion Microinflammation directly influenced the curative effect of Erythropoietin in non-dialysis CRF patients. Serum IL-6, TNF-a and CRP concentrations were negatively correlated with the increased Hb level .