Kidney Vent The Observation Of The Efficacy Of The Drug Particle Treatment Of Chronic Renal Failure And The Impact On Serum Pth And Epo

Chronic renal failure, being a common obstinate disease clinically, is the ultimate outcome of multiple renal diseases. The study of non-dialysis therapy for chronic renal failure, including the application of traditional Chinese medicine, has significant meaning in delay the development of disease progress.This study consists three main part including reference research, experience inheriting and clinical research.In the reference research part, there were two major references. The first one, "The study development of therapy approach for chronic renal failure using Traditional Chinese Medicine", mainly introduced the opinion of Traditional Chinese Medicine for chronic renal failure, the current situation of chronic renal failure therapy using TCM clinically and the development of mechanism for Chinese herbal medicine functioning. The second reference, "the related research development of opinion in modern medicine for chronic renal failure", mainly discussed the opinions for chronic renal failure in the angle of modern medicine, and especially highlighted the current clinical situation of non-dialysis therapy for chronic renal failure.In the experience inheriting part, named after "Clinical experience in chronic renal failure therapy of Prof. Lifang Nie". In this part, we discussed the disease name and stage in Traditional Chinese Medicine, etiology and pathogenesis, therapy method for chronic renal failure, and summarized the clinical experience of Professor Lifang Nie in treatment of chronic renal failure. My tutor thinks that it is more appropriate to name chronic renal failure as GuanGe in TCM through the collation of disease research.And tutor believes that the cause of chronic renal failure include primary cause and remote cause. The clinical approach of my tutor treating chronic renal failure is discrimination of the disease period at first, and then careful differentiation, combination of above both finally.In the study part, named as "the observation on therapeutic effect and impact on serum EPO and PTH after application of Bu-shen-xie-du granule in therapy of chronic renal failure". Objective: To observe the clinical effect and impact on serum EPO and PTH in renal failure patient after using Bu-shen-xie-du granule (experience preparation of supervisor). Method, There were 60 chronic renal failure cases which was randomly divided into two groups with 2:1 proportion: therapy group (40 cases) and control group (20 cases). Bu-shen-xie-du granule was applied for the therapy group, and Niao-du-qing granule for control group. For all patients in both groups, they accepted same basic therapy (including diet and symptomatic treatment). The treatment course was 8 weeks, the changes in clinical symptom, renal function, hemoglobin (Hb) and hematocrit (HCT) were observed. We also detected the serum PTH and EPO before and after the application of Bu-shen-xie-du granule in treatment of chronic renal failure (n=43). Result: the total effective rate was 80.75% in therapy group, and 65.00% in control group, with significant difference between two groups, P<0.05, which suggested the better effect of therapy group compared with control group. In the treatment of syndrome, the overall effect rate in therapy group was 87.50%, higher than the 55.00% in control, with significant difference, P<0.05. After the treatment in both groups, the hemoglobin level and hematocrit were prominently elevated, serum creatine and BUN level were decreased obviously, but the effect in therapy group was better than control group with significant difference, P<0.05, P<0.01. After treatment with Bu-shen-xie-du granule, the chronic renal failure patients with renal anemia (n=43) has shown elevation of serum EPO level, with significant difference compared with before treatment, P<0.01. After therapy, the serum PTH was significantly decreased accompanied with the elevation of calcium level, which proved to have significant difference, P<0.01. Conclusion: Bu-shen-xie-du granule not only has the effect to improve the clinical symptom and physical sign for chronic renal failure patients, improve renal function and correct renal anemia as well as elevate EPO level, but also can inhibit the high PTH disease in chronic renal failure patients, modulate the disordered calcium-phosphate metabolism, and delay the progress of chronic renal failure.