The Changes And Significance Of Serum SCD40L And SE-selectin In Patients With Type 2 Diabetes Mellitus

Obejective The aim of this study was to investigate the changes of serum soluble CD40L (sCD40L) and soluble E-selectin(sE-selectin)and their roles in the pathogenesis of diabetic microangiopathy, and to provide evidence for early diagnosis and treatment of diabetic microangiopathy.Methods Serum levels of sCD40L and sE-selectin were measured with ELISA in thirty two cases of type 2 dibetic patients(12 patients with and 20 without overt diabetic microangiopathy)and twenty cases of healthy subjects.Results 1.(1)Serum levels of sCD40L in type 2 diabetic patients with and without microangiopathy were significantly higher (P<0.01) than those in healthy controls (3. 96±0. 92ng/ml,3.07±1.25 ng/ml versus 1.65 ±1.26ng/ml, respectively) (2)Serum levels of sCD40L in type 2 diabetic patients with microangiopathy were significantly higher (P<0.05) than those in type 2 diabetic patients without microangiopathy (3.96±0.92 ng/ml versus 3. 07±1.25 ng/ml, respectively)2. (1)Serum levels of sE-selectin in type 2 diabetic patients with and without microangiopathy were significantly higher(P<0. 01) than those in healthy controls (70.78±7. 11 ng/ml,54.57±6.19 ng/ml versus 36.38±3.92ng/ml, respectively) (2)Serum levels of sE-selectin in type 2 diabetic patients with microangiopathy were significantly higher (P<0.01) than those in type 2 diabetic patients without microangiopathy (70.78±7.11 ng/ml versus 54.57±6.19ng/ml, respectively)3. Serum levels of sCD40L in type 2 diabetic patients had positive correlative with serum levels of sE-selectin (r=0.805, P<0.01). Triglycerides, total cholesterol, HbA1C, FPG and age didn' t correlate...