Preparation Of Transfersomes And Liposomes Complexed With Combind Salvia Miltiorrhiza

BACKGROUND:Transfersomes (TF) are new , ultradeformable carriers with characteristics thatenable themself to penetrate the skin spontaneously . TFs are able to noninvasively transport both low-and high-molecular-weight molecules into the body. This work describes a novel vesicular drug carrier system called transfersomes, which is composed of phospholipid, surfactant, and water for enhancing transdermal delivery. The transfersomal system was much more efficient in delivering both a low and high molecular weight drug into the skin.The percutaneous route for drug administration has many advantages over other pathways, including avoidance of first pass effect, delivering drugs continuously, having fewer side effects, and improving patient compliance. However, the barrier nature of skin inhibits the penetration of most drugs. The use of lipid vesicles in a delivery system for skin treatment has attracted increasing attention in recent years, but it remains controversial. Some studies reported the disadvantages of liposomes resulted from their components.To overcome the above problems, a novel type of highly deformable lipid...