| The trauma is an important disease in the general population and leds to death million per year. It is worry for us that the trauma individuals is estimated to increase doublily in the 21 century by specialist .So, Improved wound healing has represented a major clinical problem for the patients and a need for improving the quality of the wound recovery. Although many studies are focused on how to accelerate wound healing and many reparative factors have been founded to accelarete proliferation and anti-apoptosis,such as the growth factors(bFGF,KGF,et al) are the most representative among the many factors,it is hard to receive ideal cure effects because of the reduced levels of active growth factors in the wound environment, mutation of the receptors of growth factors, excessive proteinase activity, imbalance between proteinases and their inhibitors and adverse reaction of raising scar of some factors.Thus, the application of these factors is limited.Therefore, It is very important to study the mechanism of normal wound healing and seek new proliferation -promoting factors of non-receptor pathway.C-ski is cellular homolog of v-ski gene,distributes widely in many kinds of tissues and cells. Overexpression of c-ski promotes quail embryo fibroblasts proliferation and induces muscle differentiation in quail embryo fibroblasts. C-ski is transcriptional co-repressors that inhibit transforming growth factor-beta(TGF-beta) signaling through interaction with Smad3,Smad2 protein.C-ski is also a versatile regulator of transcription that has been shown to stimulate transcription of NFI(the nuclear factor I)and represse transcription of Rb. C-ski activities are required for development of nervous system and neural axis formation, hematopoietic cell proliferation and differentiation, tumorigenesis and reorganization. What's role it plays in wound healing?In 1999, NIH group firstly reported that the Smad3-null mice paradoxically show accelerated cutaneous wound...
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