Expression Of HOXA-10 And Progesterone Receptor In Tubal Epithelium And Its Relationship With Ectopic Implantation Of Fallopian Pregnancy

Objective: Ectopic pregnancy is frequent surgical abdomen of Obstetrics and Gynecology, which is the leading cause of maternal death in the first trimester of pregnancy. About 95% of ectopic pregnancies occur in the oviduct. In recent years, the incidence rate of it is rised. The molecular mechanisms underlying ectopic implantation in such cases have not been well characterized. Generally accepted, ectopic pregnancy often results from salpingitis and tubal damage. 55% of the cases of ectopic pregnancy occur in fallopian tubes without macroscopically evident disease.Recent investigation indicates that homeobox genes (HOX genes) are transcription factors that are essential for embryogenesis and development of the endometrium. HOXA-10 is a homeobox gene, which is necessary for endometrial receptivity to blastocyst implantation. Generally accepted, HOXA-10 plays an important role for blastocyst to implantate in the endometrium. But there is no report about the expression of HOXA-10 in ectopic implantation of fallopian pregnancy.Progesterone receptor (PR) expression varies cycling during normal menstrual cycle, with up-regulation in the proliferative stage, but with dramatic degression or even disappearance during mid-secretory phase, the time of implantation. Loss of the PR is exhibited in the mid-secretory endometrium, which is closely correlated with the establishment of uterine receptivity and is...