Experimental Studies On The Release Of Anti-infective Drug Delivery System And The Rabbits' Radial Bone Defects Repaired With It

Bone defects are common Orthopeadic clinical problems and are difficult to heal using current therapies. Previously, these cases have been treated by surgery, using techniques such as autologous and allogroup bone grafting or artificial bone grafting. However, these treatments still have a number of problems. The infected bone defects are frequent complications with treatments, Traditionally, we proceed with debridement or clearance of focal lesion and do not use a bone graft to repair the defect until wound closure and no evidence of infection present themselves by 3-6 months after injury. However, the primary bone grafting has been considered a contraindication in this situation because of the associated higher infection rate. This adds adversely to the difficulty in treatment and increase hospital stay and financial burden to the patients. So it is very important to make a new type material with anti-infection and high performance active osteogenesis.1. The bBMP was extracted from the fresh cortex of the four limbs of the young ox and its bone formation inductive activity was determined. The bBMP had strong bone formation inductive activity. At the third day when it was buried in the muscles of the behind legs of the mouse, there were a large number of mesenchymal cells around the bBMP and at the seventh day the...