Expression And Significance Of Fhit, Survivin During The Pathogenesis And Development Of Breast Carcinoma

Backgroud and Objective:Breast carcinoma is one of the most common malignancy and the main cause of carcinoma mortality among women . About 400000 women die of breast carcinoma in the world each year.It is important to investigate the mechanism of breast carcinoma development and progression, because of high incidence of breast carcinoma pathogenesis and mortality. Only find the mechanism of breast carcinoma development and progression, could we obtain more basis to the research work on prevention and therapy of breast carcinoma. There are multiple genetic changes invovlved in their genesis and progression, including the activation of proto-oncogenes and inactivation of tumor suppressor gene. The Fhit(Fragile Histidine triad)gene is a probable tumor suppressor gene, it's located at 3p14.2 and encompasses the FRA3B fragile site and the breakpoint of the (3:8)translocation associated with familial renal cell carcinoma. The Fhit gene is expressed at low level in various human tissues. Whereas the high frequency loss and/or aberrant transcripts of Fhit has been reported in various human carcinomas, inactivation eventually lead to lack of normal anti-oncogene expression in tumor cell. Abnormal structure or expression of Fhit gene in breast carcinoma have been reported abroad. Normal expression of Fhit protein was observed in normal breast tissue and loss or aberrant in...