The Analysis Of TP And PCNA Association With Proliferation,Metastasis And Prognosis In Gastric Carcinoma

Objective: To investigate the meaning and association with prognosis of TP and PCNA expression in gastric carcinoma.Methods: The expression of TP (thymidine phosphorylase ) / PD-ECGF (platelet-derived endothelial cell growth factor) and PCNA (proliferating cell nuclear antigen) were detected by immunohistochemistry method.Results: â‘  the expression rate of TP and PCNA were67.9%, 71.7 % respectively. â‘¡the expression of TP and PCNA in gastric carcinoma were Positively associated with invasive depth, histology differentiation and lymph node metastasis(P<0.05), PCNA was correlate with tumor size (P<0.05), while TP was not correlate with it (P > 0.05). â‘¢ TP was significantly correlated with PCNA in gastric carcinomas (P<0.01 ) . â‘£TP-positive group have a good prognosis with 2-year, 3-year survival rate and overall survival value in 22 cases who adjuvant chemotherapy (P<0.05 ) , whereas reverse result was found in 31 cases who didn't adjuvant chemotherapy about 2-year, 3-year, 5-year survival rate and overall survival value (P<0.05 ). Cases who adjuvant chemotherapy have a better prognosis in 2-year, 3-year and 5-year survival rate and overall survival value than those who didn't adjuvant chemotherapy cases in 36 TP-positive cases (P<0.01 ) ; No visible...