The Relationship Among Retinopathy In Type 2 Diabetes Mellitus And Serum SICAM-1,sVCAM-1

Objects Diabetic retinopathy (DR) is one of the most common complications of diabetes, and is the main cause of blindness among adults. DR has complicated pathogenesy and is the result of multiple factors synergy. One of the central pathological changes is the adherency and aggregation of blood leucocyte and retina micrangium endotheliocyte in its occurrence and development. Results showed raised serum levels of adhesion molecules are believed to reflect endothelial activation and may contribute to the development of diabetic vascular complications. The aim of this study was to clarify the association between soluble adhesion molecules levels and retinopathy in type 2 diabetic patients.Methods 70 cases of type 2 diabetes mellitus patients who were diagnosed definitely according to 1999 World Health Organization Criteria were recruited into the study. They were classified into three subgroups according to eyeground photography: patients without retinopathy (NDR, n=20), patients with background retinopathy (BDR, n=25), and patients with proliferative retinopathy (PDR, n=25). 15 healthy subjects were researched as control (CON). Levels of serum sICAM-1 and sVCAM-1 were measured by enzyme-linked immunosorbent assay (ELISA). Neither the controls nor the diabetic patients had allergies, inflammatory disease, malignancy, or hepatic disease. Blood pressure, hemoglobin A₁C(HbA₁), and serum glucose, total cholesterol (TC), triglyceride (TG),high density lipoprotein cholesterol(HDL), low density lipoprotein cholesterol (LDL),urea nitrogen, and...