Expression And Significance Of JAB1, Cx43 And P27～(Kip1) In Pathological Scar

Objective: To study the expression of JAB1, Cx43 and p27^kip1 in the pathological scar and their mutual relationship, then to investigate their roles and probable mechanism in the pathogenesis of abnormal scar.Methods: Immunohistochemistry and computerized imaging analysis were used to detect the expression and distribution of JAB1, Cx43 and p27^kip1 in keloid, hypertrophic scar and normal skin. Statistics was used to analyze the data.Results: JAB1 expression was much higher in keloid(Mean IOD 6927.81±805.05) and hypertrophic scar(Mean IOD 6652.01±870.82) than in normal skin(Mean IOD 2553.91±554.67)(P<0.01). p27^kip1 expression was much lower in keloid(Mean IOD 1258.86±406.09) and hypertrophic scar(Mean IOD 1481.82±575.74) than in normal skin(Mean IOD 2553.91±554.67) (P<0.01) . Cx43 expression was much lower in keloid(Mean IOD 1438.39±403.39) and hypertrophic scar(Mean IOD 1748.07±393.99) than in normal skin(Mean IOD 3281.32±694.06) (P<0.01). There was no...