The Effect And Mechanism Saffor(Carthamus Tinctorius L.) Injection On Renal Ischemia/Reperfusion In Rats

Objective : To study the protection and mechanism of saffor injection on renal ischemia/reperfusion injury in rats .Methods:Seventy-five Sprague-Dawley rats were randomly divided into five groups (n=15,in each), normal control group, ischemia/reperfusion group, low-dose treatment group, middle-dose treatment group and high-dose treatment group. The rat's RIRI model was established by resecting the right renal firstly, followed by blocking the blood flow of left renal for 45 min, at last reperfusion 24 hours. All groups need to establish RIRI model except the normal control group which was established by only cutting abdomen and then closing the incision. Each group was dealt as follow. The normal control group were injected with physiological saline(NS) 3ml/kg through caudal vein three days before operation and each 8 hours after operation. The ischemia/reperfusion group was dealt the same as normal control group. All treatment groups were injected with saffor injection(low-dose 1.25 ml/kg,middle-dose 2.5 ml/kg,high-dose 5 ml/kg ) through caudal vein three days before operation and each 8 hours...