The Variable Number Of Tandem Repeat Polymorphism In The P-selectin Glycoprotein Ligand-1 Gene In Relation To Coronary Heart Disease

Objective: Inflammatory genes are thought to represent an important functional groupin the atherosclerotic disease process. Single nucleotide polymorphisms and lengthpolymorphisms, such as variable number of tandem repeats may have effects on thestructure and function of P-selectin and P-selectin glycoprotein ligand (PSGL)-lproteins and thus may play a role in coronary heart disease by alteration of bindingproperties. This article is to investigate the correlation between the variable numberof tandem repeat polymorphism in the P-selectin glycoprotein ligand-1 gene andcoronary heart disease .Methods: A total of 192 patients with angiographically confirmed coronary heartdisease and 188 controls were genotyped for the variable number of tandem repeatpolymorphism in the P-selectin glycoprotein ligand-1 gene by polymerase chainreaction (PCR) analysis.Results: The variable number of tandem repeat polymorphism in the P-selectinglycoprotein ligand-1 gene has been found no correlation with coronary heart disease,as well as the number of pathological branches of coronary artery or the types ofcoronary heart disease.Conclusion: The relationship of the variable number of tandem repeat polymorphismin the P-selectin glycoprotein ligand-1 gene and coronary heart disease is still needto be discussed.