The Study On The Distributive Regulation Of TCM Symptom-sign In Lupus Nephritis Patients

ObjectiveTo investigate the distributive regulation of TCM symptom-sign in LupusNephritis patients of Guangdong Hospital of Traditional Chinese Medicine,and the correlations between TCM symptom-sign and clinical classes,renalpathological classes,some indexes of tests.MethodsAccording to the diagnostic criteria of systemic lupuserythematosus(SLE),inclusion criteria and exclusion, 86 patients of lupusnephritis(LN) were enrolled. We collected the patients'symptom-sign of TCM.In the light of the syndrome differentiation stadard of SLE and chronicnephritis in Traditional Chinese Medicine, we ensured the symptom-sign ofTCM of everyone. Ask for the help of covariance software of the SPSS11.0,firstly used frequency to analysis the distribution of TCM Symptom-sign fromthe one dimensional level. Then we used K-means cluster method to classifyconstitute factors of the characteristic syndrome for the LN patients, namelyaccording to the syndrome content characteristics of each case to divide thecategories. Thus we divided the clinical compound syndrome types. Finally, askfor the help of covariance software of the SPSS11.0, we concluded thecorrelation between TCM symptom-sign and clinical classes,renal pathologicalclasses,some indexes of tests.ResultsThe frequency analysis showed that blood stasis syndrome(57cases, covered66.3％) was common in evil-excess syndromes. Damp-heat syndrome was the second(39 cases, covered 45.3％), then was water-pathogen syndrome and hot-poisonsyndrome. Deficiency of QI of the spleen and kidney is the major type (43 cases,covered 50％) in root-deficieny syndromes, insufficiency of both QI and YIN also had a higher occurrence (19 cases, covered 22.1％), but deficiency of YANYof the spleen and kidney syndrome and deficiency of YIN of the liver and kidneysyndrome had a low occurrence. All the syndromes had a higher occurrence inthe stage with a higher activity of the SLE.In all the patients, the root-deficieny, evil-excess syndrome(65 cases,covered 75.6％)had a highest occurrence, but root-deficieny syndrome(13 cases,15.1％),evil-excess syndrome(8 cases, 9.3％) were very few. For example, therewere only 13 patients with hot-poison syndrome(covered 15.1％), 3 patientswith deficiency of QI of the spleen and kidney syndrome(covered 3.5％), 1patient with insufficiency of both QI and YIN syndrome(covered 1.2％),but 23patients with deficiency of QI of the spleen and kidney, water-pathogensyndrome(covered 26.8％), 18 patients with insufficiency of both QI and YIN,damp-heat syndrome(covered 20.9％),17 patients with deficiency of QI of thespleen and kidney, damp-heat syndrome (covered 19.8％),ect. Blood stasissyndrome occur in many evil-excess syndromes and the root-deficieny,evil-excess syndromes. There were 57 patients with blood stasis syndrome, itcovered 66.3％.K-means cluster method showed that there are six clinical compoundsyndrome types in Guangzhou City: deficiency of QI of the spleen andkidney, water-pathogen and blood stasis syndrome; insufficiency of both QI andYIN, damp-heat and blood stasis syndrome; deficiency of QI of the spleen andkidney, damp-heat and blood stasis syndrome; hot-poison syndrome;deficiencyof YIN of liver and kidney, damp-heat and blood stasis syndrome;deficiencyof YANG of spleen and kidney, water-pathogen and blood stasis syndrome.There are some correlations between TCM symptom-sign and clinicalclasses (P＜0.05), but no correlation between it and renal pathological classes(P＞0.05).TCM symptom-sign is correlated with active indexes of renalpathological tissue (P＜0.01), but not correlated with chronic indexes of renalpathological tissue (P＞0.05). There are some correlations between TCMsymptom-sign and proteinuria of 24 hours (P＜0.05), but no correlation betweenit and complement, anti--Sm and other serum antibodies (P＞0.05).ConclusionThe root-deficieny, evil-excess syndrome is the most important TCMsymptom-sign in Guangzhou City, but root-deficieny syndrome,evil-excesssyndrome are very few. That is to say: deficiency of QI of the spleen and kidney syndrome, insufficiency of both QI and YIN syndrome, deficiency of YANY of thespleen and kidney syndrome are very common in Lupus Nephritis patients, anddamp-heat syndrome, water-pathogen syndrome, blood stasis syndrome were allaffliated to the above root-deficieny syndromes.There are six clinical compound syndrome types in in Lupus Nephritispatients of Guangzhou City:deficiency of QI of the spleen andkidney, water-pathogen and blood stasis syndrome; insufficiency of both QI andYIN, damp-heat and blood stasis syndrome; deficiency of QI of the spleen andkidney, damp-heat and blood stasis syndrome; hot-poison syndrome;deficiencyof YIN of liver and kidney, damp-heat and blood stasis syndrome;deficiencyof YANG of spleen and kidney, water-pathogen and blood stasis syndrome.There are some correlations between TCM symptom-sign and clinicalclasses, but no correlation between it and renal pathological classes. TCMsymptom-sign is correlated with active indexes of renal pathological tissue,but not correlated with chronic indexes of renal pathological tissue. Thereare some correlations between TCM symptom-sign and proteinuria of 24 hours,but no correlation between it and complement,anti--ds--DNA,anti--Sm and otherserum antibodies.