Expressions Of CXCR4 And VEGF And Their Relationship With The Invasiveness Of Pituitary Adenoma

Objiective Through exploring the expressions of CXCR4 (the Chmokine stromal cell-drived factor-1 receptor) and VEGF (Vascular endotheline growth factor) in invasive pituitary adenoma,To investigate the relationship between CXCR4,VEGF and the invasiveness of pituitary adenoma, and offers theoretical and experimental evidence for studying invasive adenoma.Methods The protein expression of CXCR4 and VEGF were examined by immunohistochemical SABC method in 39 invasive pituitary adenoma and 9 noninvasive pituitary adenoma.The multifunction true chromatic colour pathological analytical system(provided by The Aviation Spaceflight University Picture Pattern Centre in Bei Jing )was used to evaluate the expression levels of the CXCR4 and VEGF.Results Expression of CXCR4 and VEGF were found in 38 invasive pituitary adenomas and 9 noninvasive pituitary adenomas.The expression level of CXCR4 and VEGF increased obviously accompany with the increasing of the grade of invasiveness of pituitary adenoma (P<0.05) . Almost each group was significantly different (P<0.05) . but there is no significant different between invasive pituitary adenoma of grade 1 and grade 2.The expression of CXCR4 was significantly positive correlated with VEGF. (r=0.653, P<0.01)Conclusions(1) The expression of CXCR4 and VEGF increased with the increase of grades of invasiveness of pituitary adenoma, and may contribute to invasive of pituitary adenoma.(2) There is significant positive correlation between the expression of CXCR4 and VEGF in invasive pituitary adenoma. they have significance to evaluate the invasiveness biological behavior of pituitary adenoma, and can provide evidence for instituting reasonable therapy scheme, judgging prognosis and assessing curative effect in clinic.