Clinical Study Of Jin Fu An Decoction Of Cure On Medium Or Late Stage Non-small Cell Lung Cancer

[Objective]To obsever the therapeutic efficacy of Jin Fu An Decoction in treating medium or late stage non-small cell lung cancer.[Methods]90 patients with medium or late stage non-small cell lung cancer were divided randomly into three groups. In Groupâ… , 30 patients were treated with chemotherapy (NP or CP or TP) alone. In Groupâ…¡, 30 patients were treated with Jin Fu An Decoction alone. In Groupâ…¢, 30 patients were treated with Jin Fu An Decoction and chemotherapy(NP or GP or TP). The therapeutic efficancy of the three groups were evaluated after one course of treatment. Observe part of the clinical check-up indexes periodically, for example, blood shapes, liver and kidney functiong, immune function and the changes of tumors, and use Functional Assessment of Cancer Threapy-Lung (FACT-L) to evaluate the quality of life.[Results]The Groupâ…¢and Groupâ…¡have better effects in the remission of symptoms such as febrility, cough, hemoptysis,polypnea,debility,pectoralgia than Groupâ… (P＜0.05 or P＜0.01). But there is no significant difference between the Groupâ…¢andâ…¡(P＞0.05). The stable rate (CR+PR+SD) of Groupâ…¢is 90%, it is the highest one among the three groups. Groupâ… (86.67%)and Groupâ…¢(90%) have significant difference comparing with Groupâ…¡(66.67%) (P＜0.05), but three is no significant difference in stabilize the tumor between Groupâ… and Groupâ…¢(P＞0.05). Furthermore, comparing with Groupâ… , Groupâ…¡andâ…¢have better effects in the alterations of WBC,RBC,HCB,liver function, and have statistical difference(P＜0.05). However, the Jin Fu An Decoction has no severe adverse reactions. In the percentage of LBT and CD₄⁺, CD₈⁺, CD₄⁺/CD₈⁺ in T-lymphocyte subcategory, Groupâ…¢and Groupâ…¡could increase it statistically, and have no significant difference in statistics between them (P＞0.05). Jin Fu An Decoction could discrease the percentage of CD₈⁺ in T-lymphocyte subcategory statistically while the percentage of CD₈⁺ in T-lymphocyte subcategory in Groupâ… is not significant. During the treatment, Groupâ…¢has less adverse reactiont, such as nausea,vomiting,diarrhea,than Groupâ…¡, and there is significant difference between the two groups. Comparing with Groupâ… , Groupâ…¡andâ…¢have significant difference in increasing the weight (P＜0.05). And Jin Fu An Decoction could elevate the patient's Quality of life(QOL). Comparing with the Groupâ… , the alterations of the Karnosfky scores and the score in the body condition in Groupâ…¡andâ…¢have statistical difference (P＜0.05).[Conclusion]The Jin Fu An Decoction could alleviate symptoms, improve the quality of life, increase weight, improve the immunity and stabilize the tumor in some way. But the method of using the Jin Fu An Decoction and chemotherapy (NP or GP or TP) togather has a better effect in curing the medium or late stage lung cancer patients than using Jin Fu An Decoction or chemotherapy(NP or GP or TP) alone.