The Expression And Significance Of Human Pituitary Tumor Transforming Gene Protein In The Endometrial Carcinoma

The expression and significance of human pituitary tumor transforming gene protein in the endometrial carcinomaObjectiveTo study the expression and significance of pituitary tumor-transforming gene(hPTTG)protein and its relationship with the expression of epithelia-cadherin(E-cad) in endometrioid adenocarcinoma by to exam the expression of hPTTG protein in normal endomerium, simple hyperplasia of endometrium, atypical hyperplasia of endometrium and endometrioid adenocarcinoma.MethodsImmunohistochemistry of PV-9000 polymer detection systerm was used to detected the expression of hPTTG and E-cad protein in 46 cases of endometrioid adenocarcinoma with different clinical pathologic characteristics. 8 cases of atypical proliferation of endometrium, 11 cases of simple proliferation of endometrium, 17 cases of normal endometrium including 8 cases of secret stage and 9 cases of proliferative stage, then compared and analyzed these values among each other.Results1. The expression of hPTTG protein in endometrioid adenocarcinoma is overpressed(67.4％), and hPTTG protein in atypical hyperplasia of endometrium(5/8) was significantly higher than in simple hyperplasia of endometrium(18.2％)and normal endometrium tissues(17.6％), there was a significant difference(P＜0.01). The expression of hPTTG protein in endometrioid adenocarcinoma was related to surgical-pathological stage, the grade of cellular differentiation, myometrial infiltration depth and lymphatic metastasis(P＜0.05, respectively).2. Normal expression of E-cad protein was found in all of 17 cases of normal endometrium tissue. The abnormal expression rate of E-cad protein in atypical hyperplasia of endometrium and endometrioid adenocarcinoma were higher than in normal endomerium and simple hyperplasia of endometrium(P＜0.05). The abnormal expression rate of E-cad protein in endometrioid adenocarcinoma was related to surgical-pathological stage, the grade of cellular differentiation grade, myometrial infiltration depth and lymphatic metastasis.3. The abnormal expression rate of E-cad protein in endometrioid adenocarcinoma tissues with positive expression of hPTTG protein(71.0％)were higher than in those with negative expression of hPTTG protein(20.0％), the difference is significant(P＜0.01). The abnormal expression of E-cad protein and the expression of hPTTG protein in endometrioid adenocarcinoma present positive correlation(r=0.486).Conclusions1. The expression of hPTTG protein in endometrioid adenocarcinoma was overpressed. The positive expression rate of hPTTG protein in endometrioid adenocarcinoma was related to surgical-pathological stage, the grade of cellular differentiation grade, myometrial infiltration depth and lymphatic metastasis, hPTTG protein promoted the carcinogenesis and development of endometrioid adenocarcinoma.2. The expression of E-cad protein in endometrioid adenocarcinoma was decreased, The abnormal expression rate of E-cad protein in endometrioid adenocarcinoma was related to surgical-pathological stage, the grade of cellular differentiation grade, myometrial infiltration depth and lymphatic metastasis. The abnormal expression of E-cad protein promoted the infiltration and metastasis of endometrioid adenocarcinoma.3. The abnormal expression of E-cad protein and the expression of hPTTG protein in endometrioid adenocarcinoma presented positive correlation.