Expression Of PTTG And BFGF Protein And Their Relationships With MVD In Human Invasive Pituitary Adenomas

Objective To examine the expression of pituitary tumor-transforming gene (PTTG), basic fibroblast growth factor(bFGF) and microvascular density (MVD) , and explore the relationship between those expression with invasion of pituitary adenomas and their clinical value.Methods 38 cases of invasive pituitary adenomas were examined for the expression of PTTG, bFGF protein and MVD detected by PV-9000 polymer detection system.The noninvasive pituitary adenomas and normal pituitary tissues were investigated as control groups.Results 1. The positive rate of PTTG protein was 86.84% in invasive pituitary adenomas and 23.53% in noninvasive pituitary adenomas,but no expression of PTTG protein was found in normal pituitary tissues. The expression of PTTG protein in invasive pituitary adenomas was significantly higher than those in noninvasive pituitary adenomas and normal pituitary tissues (P<0.05,P<0.01).2. The positive rate of bFGF protein was 81.58% in invasive pituitary adenomas and 29.41% in noninvasive pituitary adenomas, and 0% in normal pituitary tissues, respectively. The expression of bFGF protein in invasive pituitary adenomas was significantly higher than in noninvasive pituitary adenomas, and normal pituitary tissues (P<0.05).3. lmmunohistochemistry experiment showed higher angiogenesis was detected in the invasive group and lower in noninvasive group and normal pituitary tissue .There was a significant correlation between angiogenesis status and invasiveness of the invasive pituitary adenomas(P<0.01).There was not a significant difference of angiogenesis status between noninvasive group and normal pituitary tissue(P>0.05).4. The average quantity of PTTG protein in tissues with the bFGF protein coexpression was higher than that in those without bFGF protein coexpression (P<0.01) of invasive pituitary adenomas.5. The MVD in tissue with PTTG protein expression was higher than that in those without PTTG protein expression of invasive pituitary adenomas (P<0.05). The MVD...