Relation Between Serum High-Sensitive C-Reactive Protein (hs-CRP) And Metabolic Syndrome (MS)

Background:The metabolic syndrome (MS) was a group of complicated metabolic disorders, including dysglycemia, dyslipidemia, hypertension and obesity. The incidence of MS was increasing accompanied with high fat diet and insufficient exercise. The worldwide trends of increasing MS were well recognized and had recently become a focus of medical experts. Some studies showed that MS was associated with many inflammatory factors, such as serum high-sensitive C-reactive protein (hs-CRP), IL-6, and so on, but it didn't come to a conclusion.Our objective in this study was to estimate the correlation between hs-CRP and MS, the component of MS such as body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), triglyceride (TG) and high -density lipoprotein cholesterol (HDL-c) were involved.Methods:A total of 2453 subjects (1634 men and 819 women) who received health examination in our hospital from July, 2005 to June, 2006 were enrolled to our survey. Subjects with infection, stress, acute myocardial infarct, autoimmune disorder, malignant tumor, taking some medicine such as hormone, HMG-CoA inhibition were excluded.Diagnosis criterion of MS was according to the recommendation of 2004Chinese diabetes association.CRP level was measured using a highly sensitive immuno-turbidimetry assay. Statistical analysis:CRP value was highly skewed and normalized by logarithmic transformation in all analyses. Data were described as Mean ± standard deviation (SD). Comparisons between the quantitative data were done by two-tailed t-tests. ANOVA followed by multiple comparisons with the LSD test were used to evaluate the differences among the groups. Spearman's correlation analyses were performed between CRP and components of the MS. Logistic regression analysis was used to discern the relative risks for the development of MS. Statistical analysis was performed using SPSS software for windows, version 13. 0. P values <0.05 were considered to denote statistical significance.Results:1. 408 subjects suffered from MS. The total prevalence of MS was 16.6%. High prevalence of Obesity (36.6%), hypertension (21.9%), dysglycemia (14.4%), high TG(51.2%) and low HDL-c (4.1%) was found.2. Association between CRP value and some variants2.1 CRP value was significantly higher in male (1.57±0.57 mg/L) than that in female (1.38±0.59mg/L) (j<0.05).2.2 CRP value was increased with age(P<0.05).2.3 CRP value was higher in obesity subjects than that without obesity(P<0.05).2.4 CRP value increased with blood pressure. It was significantly higher in subjects with hypertension (P<0.05).2.5 CRP value was significantly higher in subjects with dysglycemia(P<0.05).2.6 CRP value was significantly higher in subjects with higher TG or lowerHDL-c (P<0.05).3. The hs-CRP level was significantly higher in subjects with MS (1.73 ±0.54mg/L) than those without MS (1.46±0.58mg/L) (P<0.05).The results showed a positive correlation between hs-CRP level and numbers of MS components.4. The correlation analyses indicated that hs-CRP level was positively associated with Age, BMI, SBP, DBP, FPG, 2hPG and TG. Stepwise analysis showed that hs-CRP level was associated positively with BMI, Age, TG , HDL-C, DBP . The equation was y=0.172+0.237a+0.123b-0.111c+0.052d+0.045e.5. There was a positive correlation between hs-CRP level and MS after cutting off the influences of age, sex and smoking (P<0.001).Conclusions:1. The hs-CRP level was associated with components of MS. Including hypertension, dysglycemia, obesity, higher TG and lower HDL-c.2. The hs-CRP level was significantly higher in subjects with MS than those without MS. It was higher when the number of MS components increased.3. The high hs-CRP level was a risk factor of MS.