Associations Between The Serum High-Sensitive C-Reactive Protein (hs-CRP) And The Metabolic Syndrome And Its Features

Objective:To study the associations between the serum high-sensitive C-reactive protein(hs-CRP)and the metabolic syndrome and its features. Methods:219 subjects who took part in an epidemiological investigation in Chongqing City were given 75g oral glucose tolerance test, and the levels of serum lipids, urinal acid and hs-CRP were measured. An immunoturbidimetric test was adopted to quantify the serum hs-CRP.Results:Out of the 219 subjects (126 men and 93 wemen) aged 23 to 87 years with BMI 18.1-35.7kg/m2, there were 36 subjects (16.4%) with the metabolic syndrome, 148 subjects (67.6%) with at least one of the features of the metabolic syndrome. The concentration of serum hs-CRP of the subjects with the metabolic syndrome was significantly higher than those without it, and the hs-CRP level rose gradually along with the increase of the number of the features (P<0.001). The correlation analyses indicated that the concentration of the serum hs-CRP was associated positively with age, BMI, WHR, systolic blood pressure, diastolic blood pressure, fasting plasma glucose (FPG), 2-h plasma glucose, triglyceride (TG), total cholesterol (TC), uric acid, Homa-IR, and negatively with HDL-c. Adjusting the influences of age, sex and smoking, there was a significant association between the serum hs-CRP and the metabolic syndrome (P<0.001). Conclusions:The concentration of the serum hs-CRP rises with the increase of the number of the features of the metabolic syndrome, and a high level of the serum hs-CRP is a valuable marker of the metabolic syndrome.