Experimental Study About The Protective Effect Of Propofol On Acute Renal Ischemia Reperfusion Injury In Rats

Objective: To investigate the renal protection and mechanism of propofol in acute renal ischemia reperflision injury(ARIRI) rat models. Methods: The model of rat's ARIRI was established. 63SD rats were randomly divided into 3 groups: false operating group(A group), ischemia reperfusion group (B group) and propofol group(C group). Blood urea nitrogen (BUN), creatinine (Cr), superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) were detected before I/R (Ischemic reperfusion) for 15 minutes and after I/R for 2 hours and 24 hours, and renal histopathology lesions were examined. Results: Renal histopathology lesions of Propofol preconditioning group decreased significantly after ischemia reperfusion. In I/R group, BUN and Cr serum levels increased significantly after ischemia reperfusion compared with false operating group (P＜0.05), while propofol decreased the serum levels of BUN and Cr significantly (P＜0.05). There was statistic significance of the serum levels of SOD, MDA, TNF-αand IL-6 in Propofol preconditioning group and ischemia reperfusion group group (P＜0.05). Conclusions: Propofol preconditioning to kidney could protect the kidney from acute renal ischemia reperfusion injury.