Clinical And Experimental Studies On Children's Bronchial Asthma In Catabasis Treated With Fang Xiao Mixture

Objective: By observing and probing into the etiology,pathogenesis,prevention and cure medicine of children's bronchial asthma in catabasis in clinic and experiments,we try to find medication of children's bronchial asthma in catabasis and probe into the prevention and cure elements on air-way inflammation in catabasis.Methods: In clinical study, 50 bronchial asthma children in catabasis were randomly assigned to 2 groups, 30 cases in the treatment group were treated with Fang Xiao Granulation (FXG) and 20 treated with ketotifen. We observe the change of the children's cardinal symptom, objective sign, frequency, spulmonary function and laboratory examination.In experimental study, we choose healthy Wistar mice to make models of bronchial asthma in catabasis, we observe the influence on inflammatory factor in air-way,bronchial and pulmonary pathology after drench concentrated solution of FXG.'s. Result: The clinical study shows that the treat group is better than the compact group in cardinal symptom, objective sign, frequency, spulmonary function and laboratory examination.The experimental study shows that the FXG can reduce the content of inflammatory factor IL-4 in the serum of bronchial asthma mice in catabasis, and EOS count in the peripheral blood of it, restrain the collection of EOS in bronchi and lung, alleviate air-way tracheospasm and have evident differences compared with ketotifen group. Conclusion: FXG have good prevention and cure function on asthma children's air-way inflammation in catabasis.