Study Of The Relationship Of Serum Resistin Level With Insulin Resistance And The Severity Of Coronary Atherosclerosis In The Patients With Coronary Heart Disease

Background and ObjectiveCardiovascular disease is the first fatal disease in the world. So, it is gotten more and more attention in the medical science. The research of coronary heart disease (CHD)which is the multi-etiological factors disease is also more and more hot. Insulin resistance(IR) is the importance etiological factor of CHD. When resistin(RSTN) is founded,one new road is gotten in the research of etiological factor of CHD .In the past research of relationship between serum RSTN level with IR,there were two completely different results. One is serum RSTN level correlate with IR. The other one is serum RSTN level unrelate with IR. The relationship between serum RSTN level with severity of artherosclerosis have gotten two completely different results too.The purpose of present study are as follows: 1.to investigate the relationship between serum RSTN level with IR; 2. to investigate the relationship between serum RSTN level with severity of coronary artherosclerosis.Methods1.There have 57 patients with CHD which accept coronary arteriography successfully from November,2005 to April,2006. According to the result of coronary arteriography, The 57 patients were divided into two group , experimental group-the level of stenosis≥50%(n=45)and control group-the level of stenosis<50%(n=12). Remove stand: the patients have liver disease,kidney disease,pancreas disease and thyroid disease.2. General state of health:sex, age, body height, body mass, body mass index(BMI). 3. Fasting plasma glucose(FPG) and Fasting serum RSTN (FSR) in 57 patients were assayed by were assayed by enzyme-linked immunoassay. Fasting serum insulin(FSI) were assayed by radioimmunoassay. 4. The severity of coronary artery atherosclerosis was quantified with a modified Gensini score on the basis of angiographic imaging.5.All data are analyzed SPSS10.0Results1.FSI,modulus of ISI and FSR in the patients with CHD were found significantly higher than in control group(P<0.01).2.The patients with CHD show a positive correlation between serum RSTN and FSI, (r=0.303,P<0.05), FSR related significant positively with the Gensini score of coronary stenosis, (r=0.38,P=0.01).FSR related negatively with ISI,(r=-0.296,P<0.05).3.The serum RSTN was a independence influencing factor to the Gensini score of coronary stenosis(R2=0.224,P=0.01)and FSI(R2=0.120,P<0.05).Conclusion1.FSR level in the patients with CHD correlate positively with IR.The hyperesistinmia maybe is one cause of IR.2.RSTN maybe participate in coronary artery stenosis. The level of FSR may be beneficial to predict the severity of coronary artherosclerosis.