Study On The Relationship Between Insulin Resistance, Ifbrinolytic System And Severity Of Coronary Artery Lesion And The Relationship Between Insulin Resistance And Ifbrinolytic System In Coronary Heart Disease Patients Without Diabetes

ObjectiveTo investigate the relationship between insulin resistance and severity of coronaryartery lesion; the relationship between fibrinolytic system and severity of coronary arterylesion; the relationship between insulin resistance and fibrinolytic system Coronary heartdisease patients without diabetes.Material and methods200non-diabetic patients received coronary angiography were enrolled, who weredivided into the group of normal glucose tolerance and the group of abnormal glucosetolerance, and the above two groups is further divided into four groups respectivelyaccording to the number of diseased vessels: one vessel diseased group, two vesselsdiseased group, three vessels diseased group and control group. The blood pressure, heightand weight were measured; Plasma insulin (FINS), fasting plasma glucose(FPG),plasminogen activator inhibitor-1(PAI-1), total cholesterol(TC), triglycercide(TG) and lowdensity lipoprotein cholesterol(LDL-C) were measured; Body mass index (BMI),homeostasis model assessment of insulin resistance index (HOMA-IRI) and Gensini’sscore of coronary artery were calculated in the group of normal glucose tolerance and thegroup of abnormal glucose tolerance.ResultsCompared with the control group, in the group of normal glucose tolerance and thegroup of abnormal glucose tolerance, FINS、HOMA-IRI、PAI-1、TC、TG、LDL-C levelsin CHD groups increased significantly（P <0.05）; the number of vessels involved allsignificantly increased with Gensini’s score、 HOMA-IRI and PAI-1, The differencesamong all groups were significan（tP <0.05）; Partial correlations showed that HOMA–IRIpositively correlated with Gensini’s score (r=0.523，P=0.02)，PAI-1positively correlatedwith Gensini’s score (r=0.415， P=0.03)after adjusting the influential factors; Multivariate linear regression model showed that Gensini’s score and PAI-1wereindependent factors for HOMA–IRI; BMI, HOMA-IRI and Gensini’s score wereindependent factors for PAI-1.ConclusionThe degree of Insulin resistance and fibrinolytic system is closely correlated with theseverity of coronary artery stenosis in coronary heart disease patients without diabetes, andthat they are both independent factors for each other.