Kakkonein Depress The Angiogenesis Caused By Angiotensin-converting Enzyme 2(ACE2)

Purposes:â‘ Observe the variation of the angiotensin- converting enzyme 2(ACE2) in the heart of rats post- myocardial infarction.â‘¡Observe whether or not the kakkonein have the contribution to angiogenesisâ‘¢Observe kakkonein whether of not to affect the expression of ACE2. Methods: Manufacture the models of myocardial infarction with coronary artery ligation, to put to death at 3,7,14,28or90 days later respectively.Partial individuals accept the kakkonein solution through intramuscular injection (respectively, used 20,40,80mg/kg/d ),killed at 28 days later of coronary artery ligation. Detect the variation of ACE2, CD31 and capillary density in heart. Results: After coronary artery ligation,all of the quantity of the ACE2 protein , CD31 protein and capillary density are increased; All of the quantity of the ACE2 protein , CD31 protein and capillary density of the individuals treated with kakkonein are descented. The variations of ACE2 , CD31 and capillary density are coincident. Conclusions:â‘ The ACE2 is increased in heart post-myocardial infarction.â‘¡ACE2 has the contribution to angiogenesis; Kakkonein has the opposite action.â‘¢Kakkonein depress the ACE2's elevation in heart post-myocardial infarction.