Expression And Significance Of Tumor-Associated Antigen RCAS1 In Nonsmall Cell Lung Carcinoma

Objective: To explore the relationship between the expression of tumor-associated antigen RCAS1(receptor-binding cancer antigen expressed on SiSo cells) and clinical pathological factors in nonsmall cell lung carcinoma and study the clinical significance of RCAS1.Methods: Immunohistochemical SABC method was used to detect the expression of RCAS1 in 61 nonsmall cell lung carcinoma tissues, 10 benign lung tissues and 10 normal lung tissues. The relationship between the expression and clinical pathology was analyzed.Results: The positive rate of RCAS1 in nonsmall cell lung carcinoma was significantly higher than that in normal lung tissues(P<0.05). But there was no significant difference between the expression or rate of RCAS1 in nonsmall cell lung carcinoma and benign lung tissues(P>0.05). RCAS1 expression in nonsmall cell lung carcinoma was correlated with tumor differentiation and clinical staging(P<0.05), but not with age, sex, smoking, pathological type and lymph node metastasis(P>0.05).Conclusions: RCAS1 may participate in the onset and progression of nonsmall cell lung carcinoma. RCAS1 could be a new biomarker in the diagnosis, treatment and prognostic evaluation of nonsmall cell lung carcinoma.