| Brain can protect itself from ischemia and /or hypoxia by conditioned neurogenic neuroprotection, which is represented in intrinsic neurons in cerebellar fastigial nucleus. It can be initiated by electrical excitation of intrinsic neurons of fastigial nucleus. Fastigial nucleus stimulation can promote the recovery of neurological deficits and improve the regional cerebral blood flow and reduce the volume of a focal ischemic infarct. Some prelimilary observations of clinical application of fastigial nucleus electrical stimulation are presented, which is on protecting neurons from ischemic injury and treating patients with stroke in intermediate and advanced stage. But there is no observations on acute stage of cerebral infarction.To investigate the clinical effect of electric stimulation in cerebellar fastigial nucleus (FN) on cerebral blood flow and motor function of patients with hemiplegia induced by acute cerebral infartion in the day 1-3 post acute cerebral infartion. Sixty cases of acute cerebral infarction were randomly divided into rehabilitation treatment group (n=30) and control group (n=30). Both of them received routine drug treatment and routine rehabilitation nursing in the day 1-3 post acute cerebral infarction. The rehabilitation treatment group was treated with electric stimulation in cerebellar fastigial nucleus by using Cerebrovascular Functional Therapy (CVFT) based on routine drug treatment and routine rehabilitation nursing in the day 1-3 post acute cerebral infarction. CVFT made by Shanghai Renhe Medical Instrument Company, is based on direct digital synthesis (DDS) technology by using the domestic newest scientific findings and others in foreign countries. Adopting the DDS technology directly, it institutes safe and efficacious treatment. Through pasting the electrodes on body surface, the non-invasive instrument introduces electric current to cerebellar fastigial nucleus. Stimulative methods: once a day, 60 minutes per time and 10 days continuously. The effects on the degree of neurologic impairment before and after treatment was evaluated by the National Institutes of Health Stroke Scale (NIHSS) score and the simplified Fugl-Meyer assessment (FMA). The effect on the blood flow of injured side middle cerebral artery and anterior cerebral artery before and after treatment was observed by transcranial Doppler (TCD). All data were selected for statistical analysis for SAS 9.0.From the above work, we got the results as followed:1. It showed that there was no differenrence in the scores of neurologic impairment of NIHSS (rehabilitation treatment group: 12.70±2.58, control group: 14.11±3.35) and FMA (rehabilitation treatment group: 34.03±19.01, control group:25.11±12.74) in the rehabilitation treatment group and the control group before treatment. Compaired with the rehabilitation treatment group after treatment, the scores of NIHSS (8.10±4.00) and FMA (49.20±25.63) were in the rehabilitation treatment before treatment (t=-3.92, P<0.01; t=2.60, P<0.01) and in the control group (NIHSS: 13.11±3.47, FMA: 31.23±18.02) after treatment (t=4.32, P<0.01; t=-2.55, P<0.01).2. It showed that there was no differenrence in cerebral artery blood flow of the affected side in the rehabilitation treatment group (MCA: 90.33±29.90, ACA: 83.48±32.33) and the control group (MCA: 84.17±29.34, ACA: 77.25±37.68) before treatment. Cerebral artery blood flow in the affected side was significently increased in the rehabilitation treatment groupafter treatment as compared with that before treatment (P<0.05). There were significant differencence in the cerebral artery blood flow between the rehabilitation treatment group (MCA: 127.16±44.18, ACA: 106.43±30.22) and the control group (MCA: 89.08±28.34, ACA: 85.17±32.90) after treatment (t=-2.72, P<0.01; t=-2.24, P<0.02).3. There were no significant difference in blood pressure and heart rate (all P>0.05). All patients can endure the local excitation of electrode's place, and no obvious adverse effect.From the above results , we got the conclusion as followed:1. The patients may take the therapeusis of Fastigial nucleus stimulation, as long as their mind are clear, VS (the life symptom) steady, and the nervous system physical sign have no progress in the day 1-3 post acute cerebral infarction.2. The therapeusis of Fastigial nucleus stimulation can increase the regional cerebral blood flow and improve the degree of neurologic impairment in the day 1-3 post acute cerebral infarction.3. The therapeusis of Fastigial nucleus stimulation is no obvious adverse effect.4. TCD is the capacity to detect the regional cerebral blood flow.Fastigial nucleus stimulation can significantly increase the regional cerebral blood flow, promote the recovery of neurologic function in the affected and improve the neurologic impairment of acute infarction patient. Therefore, the therapeusis of Fastigial nucleus stimulation is helpful in the day 1-3 post acute cerebral infarction.
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