The Study On The Association Between HLAⅡ-DRB1 Alleles And Oral Lichen Planus Of Han Chinese And Uygur People In Xinjiang

Purpose To investigate the association of human leukocytes antigen HLAâ…¡-DRB1 alleles with oral lichen planus (OLP) of Han Chinese and Uygur people in Xinjiang. Methods The allele frequency of HLAâ…¡-DRB1 were detected in 34 OLP patients vs 123 normal controls of Han Chinese group and 14 OLP patients vs 42 normal controls of Uygur people group by the means of polymerase chain reaction-sequence specific primers (PCR-SSP) method.The data was analyzed by SPSS16.0 software package for Chi-square test and Fisher test.Results The allele frequency of HLAâ…¡-DRB1*11 were significantly higher (23.53% vs 9.76 % ), however, HLAâ…¡-DRB1*12were substantially lower (5.88% vs 22.76 %) in OLP patients than that in normal controls in Han Chinese group,P < 0.05.The allele frequency of HLAâ…¡-DRB1*14 were significantly higher (50.00 % vs 9.52% ) than that in normal controls in Uygur people group,P<0.05.Conclusion HLAâ…¡-DRB1*11 alleles could be the susceptible genes for OLP in Han Chinese in Xinjiang, however, HLAâ…¡-DRB1*12alleles might be the protective gene for OLP in Han Chinese in Xinjiang. HLAâ…¡-DRB1*14 could be the susceptible genes for OLP in Uygur people in Xinjiang.