The Clinical Significance Of Diagnosing NHL On The Basis Of Examining The Serum Levels Of LD, β-2-M And CA-125

Objective:To study the adjuvant diagnosis value of the three serum tumor markers, lactic dehydrogenase LDH,beta2-microglobulinβ-2-M and CA-125 in non-Hodgldn's patients.Methods:The serum levels of LDH,β-2-M and CA-125 were examined by velocity method,immunotttrbidimetry and electrochemiluminescence,including 48 patients,22 healthy persons and 8 lymphatic neagative patients.Results:1) The serum levels of LDH,β-2-M and CA-125 in non-Hodgkin patients were higher than other groups;2) There is no statistical significance in examining the serum levels of LDH,β-2-M and CA-125 in non-Hodgkin's patients in high malignancy group,middle malignancy group and low malignancy group.(P＞0.05);3) The serum levels of LDH,β-2-M and CA-125 in phaseⅢandⅣare higher than phaseⅠandⅡ.(P＜0.05);4) The serum levels of LDH,β-2-M and CA-125 in remission group after chemical treatment were decreased and have stastical significance.(P＜0.05) In non-remission group,there is no difference;5) The combined assay of serum tumor markers can enhance diagnostic value of NHL.Conculsion:1) There were no diffience between the diffient histological classification of the serum level of each tumor maker.2)The serum levels of LDH,β-2-M and CA-125 in phaseⅢandⅣare higher than phaseⅠandⅡ;3)The chang in the three serum tumor markers before and after the chemical treatment has partly reflected the effect and improved the diagnostic value of NHL;4) The three tumor markers has different adjuvant diagnosis value to NHL and the combined detection of them can enhance its clinical diagnosis value.