The Study On The Stability And Medicine Dilivery Regularity Of Plumula Nelumbinis Microcapsules

Most preparation of Plumula Nelumbinis recorded are injection.But the quality of the injection of Plumula Nelumbinis is not stabilititated.And that,as the carrier of medicament,the Microcapsules can improve the stability of medicament,slow-released,or controlled-released effect.And the target function and biological availability are better than the traditional dosage form.To study the Plumula Nelumbinis Microcapsules,it can personification the charateristic of multistrata and multitarget of Chinese Medicine,and it can efficiently elevate the stability of pharmaceutical preparation. @The study contents before include:1)the optimization of the extract technical of Plumula Nelunbinis.2)the optimization of the preparation technical of Plumula Nelunbinis Microcapsules.3)the study of anti-arrhythmia of Plumula Nelunbinis Microcapsules. @We study the Plumula Nelunbinis Microcapsules in the base of the protophase study.We approach the stability of TAL(total alkaloids of lianzixin)after microencapsulation,and to study the method of drug-released of Plumula Nelunbinis Microcapsules. @Objective: @To study the stability of TAL(total alkaloids of lianzixin)after microencapsulation;To study the dissolution rate in vitro of Plumula Nelumbinis microcapsules which were prepared with gelatin as coating material: To do electrocardiogram monitoring on guinea pigs after administration to definite the optimal dosage of Plumula Nelumbinis Microcapsules;To study the transmutation of blood plasma concentration of drugs in rabbits after administration with Plumula Nelumbinis Microcapsules. @Method: @To use remaining sample observation method to consider;The drug release was determined by ultra-violet spectrophotometry;The arrhythmia models were induced by ouabain(in guinea pig),60 model guinea pigs were divided into five dosage groups,each group were preventively administered with drugs for 5 days, and the indexes of experiment were determined and evaluated 30min after the final administration.Thus to definite the dose-effect relationship and optimal dosage;after intragastric administration on rabbits,the plasma concentration of drugs in each time point was detected by using reversed phase high performance liquid chromatography method and the data was dealt with drug and statistics program to calculate the pharmacokinetics parameters and select apartment model. @Result: @Using remaining sample observation method to check every month for one year, the content of TAL in the microcapsules remain invariably;The drug release from the microcapsules followed Higuchui model kinetics;To do electrocardiogram monitoring on guinea pigs after administration,each group showed that delayed occurrence of arrhythmia,shortened duration of arrhythmia, prolonged duration with normal cardiac rhythm were improved by dose dependent. The best dose of Plumula Nelumbinis Microcapsules is 100mg/100g; administrating rabbits with Plumula Nelumbinis Microcapsules,the time-concentration curve of TAL intravenous administration corresponded to the model of two apartments.The main pharmacokinetics parameters were: t_1/2α=1.172h,t_1,2β=17.676h,AUC=16.754mg/L*h,CL=6.254L/h/kg,Cmax=2.678 mg/L. @Conclusion: @The stability of the TAL in the microcapsule is increased after Microeacapsulation:the Microcapsules of diffent diameter have the same tendency of release;The anti-arrhythmic effects of Plumula Nelumbinis Microcapsules is dependenced on the dose:the time-concentration curve of Plumula Nelumbinis Microcapsules in rabbits corresponded to the model of two apartments.