Study On The Effective Components Of Atractylodes Plants And Atractylodes Macrocephala & Establishment Of Herbs' Element Fingerprint

Traditional Chinese medicine is the gem of China. The effective composition is the most important material basis of efficacy, toxicology and metabolism. And which has important significance in finally elucidating the mechanism of TCM therapy, in controlling product quality and in the evaluation of safety.Validity, security and stability are the most fundamental requirements of any pharmaceutical preparation. Almost one fifth of Chinese traditional medicines are decocted by water. However, the compositions and contents of the chemical components may be changed in the process of decocting. These reaction products may be the curative effect compositions, but they may also be the toxic components. Therefore, effectively monitoring the changes of components is the key points to ensure the validity, security and stability of herb drugs.Element is the basis of everything. The element fingerprint can reflect the drug efficacy and the genuineness in some extent. The element fingerprint of herb which will be provided reliable basis for the identification of false and true herb, the identification of producing area and the judgment of the genuineness.The main contents and results of this paper include:1. In the first section. We have made some researches on the chemical components changes of Atractylodes lancea and Atractylodes chinensis' Water-extract in the process of decocting, and separation and purification of the new compounds in the Water-extract. The 3, 5-dihydroxy-2-methyl-4H-Pyran-4-one and 5-(hydroxymethyl)-2-Furancarboxaldehyde were found in the Water-extract of Atractylodes chinensis but weren't found in the Water-extract of genuine medicinal materials Atractylodes lancea. This may be an embodiment of genuineness.2. We optimized the method of separation and purification of atractylenolide III which is anti-inflammation and anticancer compound. The purity of atractylenolide III was as high as 97.8%. However, this new method has the merits of low consume, low pollution and save manpower. So it can provide more suitable method for the industrial production of atractylenolide III.3. Aim to establish the element fingerprint of these herbs. We determination the content of elements in Radix Paeoniae Rubra,Paeonia lactiflora Rhubarb,Heibei Atractylodis lancea,Neimenggu Atractylodis lancea,Scutellaria baicalensis Georgi,Salvia Miltiorrhiza by ICP-MS and AAS. For provided reliable basis of the TCM genuineness and the producing area.