Expression Of Apotosis Related Protein Survivin And Caspase-3 In Juvenile Laryngeal Papilloma

Objective: The purpose of this study was to investigate the expression of Survivin protein and its relationship with Caspase-3 protein in juvenile laryngeal papilloma.Methods: The expression of Survivin protein and Caspase-3 protein were both detected with immunohistochemical method in 23 specimens of juvenile laryngeal papilloma, 23 of vocal nodules and 10 normal laryngeal mucosa.Results: The positive expression rates of Survivin protein in juvenile laryngeal papilloma and vocal nodules were 52.1 %(12/23)and 8.7% (2/23) respectively. There was a statistical significance between the two (P<0.01);And the Caspase-3 protein positive expression was detected in 95.6%(22/23) of vocal nodules, but only 26.1%(6/23) in juvenile laryngeal papilloma; Survivin was detected in none of the normal laryngeal mocusa but only one sample was negative expression with Caspase-3. The positive expression rate of Caspase-3 protein in juvenile laryngeal papilloma was significantly lower than both those of vocal nodules and normal laryngeal epithelium. Besides, there was a significant negative correlation between the expression of Survivin and Caspase-3 in the same tissue.Conclusion: The abnormal expression of Survivin and Caspase-3 may be a positive factor in the pathogenesis of juvenile laryngeal papilloma.