The Experimental Study Of The Effects Of Misture Of Thoracic Obstruction On Endothelin's Expression In Hematoplasma Of Diabetic Cardiopathy Rats

Object: To approach the effects of Misture of Thoracic obstruction on endothelin's expression in hematoplasma of diabetic cardiopathy rats. Through experimental works the curative effects and mechanism of the treatment and prevention of diabetic cardiopathy had been studied.Methods: Diabetic rat model was established by feeding high calorie diet and streptozocin-induced(STZ),and randomly divided into normal control (N),model group(M),Tong Xin Luo control group (C),low dose of Misture of Thoracic obstruction group (A₁),mid-dose group (A₂),high dose group (A₃).After 4 weeks, injected pituitrin to induce myocardial ischemia. To observe the effects of Misture of Thoracic obstruction on blood glucose, blood fat,structures changes in diabetic rat heart,and endothelin's expression in hematoplasma.Results:The rats in the M group showed that TC,TG and LDL are obviously increased compared with the N group,and HDL depressed. The content of ET sharply increased in blood plasm. Compared with Tong Xin Luo control group, Misture of Thoracic obstruction group has satisfactory hypoglycemic activity. C group and A3 group has significantly effects on the regulation of blood fat. Compared with group M,Misture of Thoracic obstruction can protect the structure of diabetic myocardiuma. Misture of Thoracic obstruction can remarkable inhibit the increase of ET in hematoplasma of diabetic cardiopathy rats.Conclusions: (1) Compared with Tong Xin Luo, Misture of Thoracic obstruction has satisfactory effects in decreasing glucose and.(2)Misture of Thoracic obstruction can regulating blood fat.(3) Misture of Thoracic obstruction can remarkable inhibit the increase of ET in hematoplasma of diabetic cardiopathy rats. (4)Misture ofThoracic obstruction can protect the structure of diabeticmyocardiuma.