Studies On The Efficacy And Mechanism Of Tangxian On Diabetic Cardiopathy

[Objective] To study the effects and its mechanisms of Tangxinan (TXA) on Diabetic Cardiopathy (DC).[Methods] To evaluate the therapeutic action of TXA on DC, rats were induced type I diabetes mellitus by tail vein injection of streptozotocin. The ECG, hemodynamics, collagen and myocardial enzymes were checked. To evaluate the preventive action of TXA on DC, rats were induced typeâ…¡diabetes mellitus by ig high-fat emulsion plus injection of streptozotocin, The ECQ hemodynamics, myocardial enzymes and myocardial cell were checked; the effects of TXA on blood glucose, glucose tolerance and arrhythmia were observed; as well as the mechanism of TXA prevent from DC by typeâ…¡diabetic rats..[Resu I ts] TXA reduced the MASSON stained area of heart in the type I diabetic rats, improved the ECG (including J-point, R-wave) and hemodynamics (LVSP, dp/ dtmax,-dp/dtmax, etc.) in the typeâ…¡diabetic rats, had a positive effect on heart electron microscopy and a decreased plasma Angâ…¡,Apelin-13 levels, has no effects on the levels of myocardial enzymes; TXA has no effect on the level of glucose in normal mice or glucose tolerance, Lee 'Index and Abdominal obesity index in obese mice; and TXA reduced the incidence of chloroform-induced ventricular fibrillation in mice and isoproterenol-induced J point of ECG in rats.[Conclusion] TXA has a positive effect in prevention and treatment of typeâ…¡diabetic cardiopathy, Its role may be related to lower levels of serum Angâ…¡, as well as direct confrontations related to the role arrhythmia, etc.