Expression Of Survivin In Endometriosis And Its Relationship With VEGF

Objective:To study the expression of Survivin and its relationship with the VEGF in angiogenesis of endometriosis.Methods:A total of 134 tissues samples were used in this study,including 58 samples of ectopic endometrium and 45 samples of eutopic endometriums of patients with endometriosis,and 31 samples of normal endometrium tissues,using streptavidin-biotin peroxidase(SP)method of the immunohistochemistry,we examined the expression of the proteins Survivin and VEGF in these tissues.Statistical analysis was performed by using SPSS10.0 statistics software.Result:1.Survivin were detected in 0/31 normal endometriums,5/45(11.1%)eutopic endometriums and 25/58(43.1%)ectopic endometrium tissues of endometriosis,the expression of Survivin in three group above has significant difference(P=0.000).2.VEGF were detected in 14/31(45.2%)normal endometriums,24/45(53.3%)eutopic endometriums and 43/58(74.1%)ectopic endometrium tissues of endometriosis,the expression of VEGF in three group above has significant difference(P=0.000).3.Survivin was strongly associated with the expression of VEGF(P＜0.05).4.The expression of Survivin and VEGF was related to the activity of endometriotic tissues (P＜0.05).5.There was no obvious correlation between the stage of endometriosis and their expression level(P＞0.05).Conclusions:1.Survivin expression could be observed in both ectopic and eutopic endometrium from patients with endometriosis and was lack of cyclic changes.So it means Survivin gene may play an important roles in the development of endometriosis. 2.VEGF expression also could be observed in both ectopic and eutopic endometrium from patients with endometriosis and it was related to cyclic changes.So it means VEGF may play an important roles in the development of endometriosis,too.3.The expression of Survivin was strongly associated with VEGF.Survivin gene stimulates the development of endometriosis by restraining the apoptosis.However,VEGF stimulates the development of endometriosis by increasing angiogenesis.Both of them may accelerate the endometriosis together.