Expression And Clinical Significance Of E-cadherin And Alpha, Beta-catenin Proteins In Human Laryngeal Cancer

Objective To investigate the roles of E-cadherin and alpha,beta-catenin play in the carcinogenesis and progression of laryngeal carcinoma.Method Immunohistochemistry staining(PV6000 two steps method) was used to detect E-cadherin and alpha,beta-catenin proteins expression in laryngeal carcinomas,normal epithelia around tumors and laryngeal papilloma.Results(1)The abnormal rates of expression rates of E-cadherin and alpha,beta-catenin in 60 laryngeal carcinomas were 55%,56.67%and 66.7%, respectively.E-cadherin and alpha,beta-catenin were all expressed normally in normal epithelia around tumors and laryngeal papilloma.The abnormal expression of E-cadherin and alpha,beta-catenin protein in laryngeal carcinoma tissucs was obviously higher than those in normal epithelia around tumors and laryngeal papilloma,respectively(P＜0.01).(2)The significant relationship was observed among abnormal E-cadherin and alpha,beta-catenin expression and differentiation,clinical stage,lymph node metastasis but not observed among abnormal E-cadherin and alpha,beta-catenin expression and tumor position, patient s'age and sex.(3)There was a positive relationship among the expression of alpha,beta-catenin and E-cadherin in same sample.Conclusion(1) E-cadherin and alpha,beta-catenin expression can be highly found in laryngeal carcinoma.(2)The abnomal expression of E-cadherin and alpha,beta-catenin may promote tumorigenesis and progression.they may be important index in evalualing the tumor differentiation,infiltration depth,lymphnode metastasis and TNM staging of laryngeal carcinoma.(3) There was a positive relationship among the expression of alpha,beta-catenin and E-cadherin in same sample,they have a joint action in tumorigenesis and progression of laryngeal carcinoma probably.