Precursor Of The Amino-terminal Pro-brain Natriuretic Peptide And High Sensitivity C-reactive Protein And Coronary Artery Disease-related Research

Backgrounds: Acute coronary syndrome(ACS) is a group of myocardial ischemic diseases, including unstable angina (UA), non ST-segment elevation myocardial infarction (NSTEMI) and ST-segment elevation myocardial infarction (STEMI). Early diagnosis and early intervention can significantly improve the prognosis of coronary heart disease.Currently,NT-proBNP and hs-CRP has been the diagnosis and assessment of heart failure patients as an important prognostic indicator widely used in clinical gradually. Recent studies show, NT-proBNP and hs-CRP in ACS diagnosis, treatment and prognosis, etc. have a certain significance. However, these studies did not exclude patients with heart failure, blood NT-proBNP and hs-CRP levels increased with the severity of coronary lesions in patients with ACS and whether the number of vascular lesions related to? Prognosis in patients with ACS are related? Have not been reported. Objective: Explore ACS in patients with coronary atherosclerosis degree and the blood NT - proBNP and hs - CRP levels of the correlation between, NT-proBNP and hs-CRP detection patients with ACS risk judgment and prognosis assessment the clinical value.Methods:ACS 120 patients,divided into unstable angina pectoris (UA) group of 40 cases, non-ST-segment elevation myocardial infarction group of 40 cases and ST-segment elevation myocardial infarction group of 40 cases, Normal physical examination in 40 patients over the same period as the control group.The severity of coronary artery lesions was evaluated by the number of diseased arteries and Gensine score.Blood NT-proBNP与hs-CRP levels were measured after admitted to hospital immediately and compared. Subjects were observed 90 days and 6 months after discharge the incidence of cardiovascular events.Results: ACS groups NT-proBNP and hs-CRP levels and Gensini score was significantly higher (P <0.01), ACS NT-proBNP levels in each group the difference was statistically significant (P <0.05), Gensini score of the group no significant difference (P> 0.05); STEMI group of hs-CRP levels and NSTEMI group and the UA group was significantly (P <0.01); NSTEMI group and UA group of hs-CRP level was no significant difference (P>0.05).Blood NT-proBNP and hs-CRP levels and Gensini score with the number of disease increases. NT-proBNP-4 each with NT-proBNP-1, NT-proBNP-2, NT-proBNP-3 comparison, differences are statistically significant (P < 0.05). hs-CRP-4 each and hs-CRP-1, hs-CRP-2, hs-CRP-3 comparison, differences are statistically significant (P<0.05).Conclusions: Blood NT-proBNP and hs-CRP levels and the degree of myocardial ischemia, coronary lesions and coronary artery disease correlated count. Blood NT-proBNP and hs-CRP levels may predict ACS in patients with elevated cardiovascular events in recent.