Study On Clinical Observation Of Homocysteine Level With Different Syndrome Types Of Traditioal Chinese Medicine Of Acute Ischemic Cerebral Disease

ObjectiveTo observe the differences of homocysteine level of plasma with different syndrome types of TCM of acute ischemic cerebral disease.To explore the relationship between the degree of neurological deficit of different syndrome types of TCM with homocysteine,then come to explore the role of homocysteine in the assessment of different syndromee types of TCM of acute ischemic cerebral disease.MethodsIn this study,with the use of forward-control research methods,we chosed patients from the emergency base of the first affiliated hospital of Guangzhou University of Traditional Chinese Medicine.during August 2008 to April 2009, In accordance with the diagnostic criteria and inclusion criteria,we selected 45 cases of subjects who are up to standard.According to the diagnostic criteria which was stipulated for syndrome types of TCM by Institute of Medicine of China Society of TCM in 1996,the patients were divided into three syndrome types of TCM.First,we collected blood samples of the patients only one-time who were In line with the inclusion criteria,and then Tested plasma homocysteine levels of all the patients.At the same time,we made out the score with the degree of neurological deficit of a variety of syndrome types of TCM of acute ischemic cerebral disease,To measure the difference between different syndrome types.At last we tested the result with statistical analysis between the data we have given with homocysteine.Results there are three syndrome types of TCM of acute ischemic cerebral disease,the first is Wind-Sputum Obstructing type,the second is Liver-Yang Hyperactivity type,the third is Sputum-Heat FU-Shi type.The results of the patients of three types with Hcy levels were8.46～14.54umol/L,15.84～24.65umol/L,16.26～55.31umol/L.In addition to the degree of neurological deficit can be divided into mild,moderate and severe type.From the Frequency Distribution Table we made according to the data above,we can see that the first type mainly to mild(62.5%),both moderate(37.5%);the second type mainly to moderate(73.3%),both mild(13.3%)and severe(13.3%);the third type mainly to severe(71.4%),both moderate(28.6%).Mild,moderate and severe in patients with three types of Hcy levels measured were 11.50±2.56,18.90±3.69,32.62±11.53.There is a significant difference with the homocysteine level in different syndrome types by statistical analysis,P＜0.05;There is a significant difference with the degree of neurological deficit in different syndrome types,P＜0.05;There is a significant difference with the homocysteine level in different degree of neurological deficit.ConclusionIn theses syndrome type groups,the homocysteine level of the third type was the highest,followed by Liver-Yang Hyperactivity type,and Wind-Sputum Obstructing type was the lowest.The degree of neurological deficit of the third type was the most serious,followed by Liver-Yang Hyperactivity type,and the Wind-Sputum Obstructing type was the lightest.The level of homocysteine rise with the degree of neurological deficit increasing.So Hcy can be used as indicator to measure the degree of neurological deficit in stroke patient's.