| Objective:To study the bone cement will be injected into osteoporosis of vertebral body in different regions,and it is to further explore the bone cement in different regions of the vertebral body distribution that the biomechanical effects of the vertebral body,to provide the theory for percutaneous vertebroplasty in the clinical application.Methods:All the spine of the human specimens soaked(including L1～L5) were soaked in the formalin.All of the specimens should be X-rayed to exclude congenital deformity,fractures,tumors and other abnormalities,determination of vertebral bone density(BMD) using dual-energy X-ray absorptiometry and separated into individual vertebral body,removal of disci intervertebrales,annex and vertebral plate etc.There are all 42 vertebral body.According to different zonation of vertebral body settings different experimental groups,all vertebral bodys were divided into 7 groups:control group and six experimental groups,and the experimental group is divided into A,B,C, D,E,F group,each group n = 6.The domestic cement(PMMA) will be injected into different districts of vertebral body and the model of examination standards to be in line by CT.All vertebral bodys were compressed in a almighty testing machine to determine intensity and to calculate the stiffness and the yield value of energy absorption,Compression was continued until the average height of the was decreased by 25%of the average initial vertebral body height.All data were expressed with X± S and treated with SPSS 11.5.Independent-Samples T test was used to compare intensity values,stiffness values and the yield value of energy absorption for control group and six experimental groups,one-way ANOVA was used to compare intensity values,stiffness values and the yield value of energy absorption for six experimental groups,whereas compare intensity values,stiffnss values and the yield value of energy absorption in six experimental groups each other;With a significance level of 0.05.Results:The intensity is(6348±455) N,(9786±382)N,(9802±348 ) N,(10665±474) N,(11558±468) N,(11571±521) N,(12597±531)N,in control group and experimental A,B,C,D,E and F group respectively.The stiffness and yield value of energy absorption were(451±54) N/mm,(46346±5206)(N/mm)~2;(605±177) N/mm,(58707±3106)(N/mm)~2;(626±48 ) N/mm,(58192±6408 )(N/mm)~2; (705±25 ) N/mm,(65973±2746 )(N/mm)~2;(792±471 ) N/mm,(76167±4600 ) (N/mm)~2;(827±438 ) N/mm,(75214±5867 )(N/mm)~2;(910±126)N/mm,(83104±2732)(N/mm)~2 respectively.There is significant difference between the intensity values,stiffness values and the yield value of energy absorption of vertebral body in control group and six experimental groups respectively(P<0.01),There is significant difference between the intensity values,stiffness values and the yield value of energy absorption of vertebral body in six experimental groups respectively(P<0.01),There is significant difference between the intensity values,stiffness values and the yield value of energy absorption of vertebral body in six experimental groups each other (P<0.01),except experimental group A and experimental group B;experimental group A and experimental group B(respectively P>0.05).It is the largest which the intensity values,stiffness values and the yield value of energy absorption of vertebral body in experiment group F,followed by experimental group E and experimental group D,the experimental group C,experimental group B and experimental group A is the smallest.Conclusion:1 The bone cement can enhance the mechanical index(intensity,stiffness and the yield value of energy absorption) of vertebral body that osteoporosis.2 The bone cement in different regions of the vertebral body distribution have different biomechanical and uniform distribution of the vertebral body is the best,but these biomechanical results have yet to be substantiated in further clinical studies.The distribution of bone cement was diffuse inside the vertebral body.4 The Bilateral distribution of bone cement have access to biomechanical indicators better than the unilateral distribution in the vertebral body5 bone cement with unilateral distribution is easy lead to unstable spine in the vertebral body,however the bilateral distribution can be obtain favourable spinal stabilization.6 The zonation theory of vertebral body in our experimental design have a guiding role for vertebral percutaneous vertebroplasty(PVP) in clinical application.
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