Preliminary Study On Relationship Between Mechanism Of Wet Heat More Emphasis On Damp-heat Syndrome Of Viral Upper Respiratory Tract Infection And Antioxidant Capacity

Objective:This research aims to search after the difference of the indicators of immune and biochemical in the patients of wet heat more emphasis on damp-heat syndrome of viral upper respiratory tract infection through prospective study and explore the internal mechanism of "middle qi excess,the disease in yangming, middle qi deficiency,the disease in Taiyin".Then observe the regulating role of antioxidant of Wormwood and Scutellaria Gallbladder Clearing Decoction treating damp-heat syndrome,and compare the treatment effect of wet heat more emphasis on damp-heat syndrome.Methods:Take prospective randomized single-blind double-dummy study,through subgroup analysis of after-the-fact,damp-heat syndrome of viral upper respiratory tract infection was divided into dampness-heat syndrome with predominant heat and dampness-heat syndrome with predominant dampness.All patients were randomly divided into Chinese medicine treatment group and western medicine control group.The paitients took Wormwood and Scutellaria Gallbladder Clearing Decoction in Chinese medicine treatment group,the ones took Ribavirin in western medicine control group.First,in research on syndrome, all paitients(70) were retrospectively syndrome differentiated into the group of dampness-heat syndrome with predominant heat(37)and the group of dampness-heat syndrome with predominant dampness(33).SOD vitality,MDA and NO were compared incidence within 48 hours in the two groups.After treatment,there were 13 cases finished Chinese medicine treatment and 7 cases finished western medicine treatment in the group of dampness-heat syndrome with predominant heat,and there were 16 cases finished Chinese medicine treatment and 9 cases finished western medicine treatment in the group of dampness-heat syndrome with predominant dampness.Western medicine treatment of the two groups togethered for a group,a total of 16 cases.SOD vitality,MDA and NO were compared in pre and post treatment in the three groups.Results:SOD vitality,MDA and NO were slightly higher in the group of dampness-heat syndrome with predominant heat than that of dampness-heat syndrome with predominant dampness before treatment,but the difference was not statistically significant.After treatment by Wormwood and Scutellaria Gallbladder Clearing Decoction or Ribavirin,symptoms and signs in each group were compared:cooling time was significantly shorter in group of dampness-heat syndrome with predominant dampness than that of dampness-heat syndrome with predominant heat.Cooling time was the shortest in group of dampness-heat syndrome with predominant dampness,then followed group of dampness-heat syndrome with predominant heat,and western medicine control group was the last. Symptoms and signs score difference was the highest in group of dampness-heat syndrome with predominant heat,the second one was group of dampness-heat syndrome with predominant dampness,the last one was western medicine control group,and the difference was statistically significant(P＜0.01,P＜0.01). Comparison of each group before and after treatment:SOD vitality didn't have significant difference between pre treatment with post one in the three group.MDA was both decreased in group of dampness-heat syndrome with predominant heat and western medicine control group,the difference was both statistically significant(P＜0.05,P＜0.01).There was also a downward trend in group of dampness-heat syndrome with predominant dampness,However,no significant.NO all decreased in three groups,the differences were statistically significant.The target were compared among three groups after treatment:SOD vitality was the highest in group of dampness-heat syndrome with predominant heat,followed the group of dampness-heat syndrome with predominant dampness,western medicine control group was the lowest.NO was the highest in group of dampness-heat syndrome with predominant dampness,followed western medicine control group,group of dampness-heat syndrome with predominant heat was the lowest.MDA was higher in group of dampness-heat syndrome with predominant dampness and western medicine control group than that of dampness-heat syndrome with predominant heat,However,no statistical significance.Conclusion:1.Wormwood and Scutellaria Gallbladder Clearing Decoction has positive effect on damp-heat syndrome of viral upper respiratory tract infection,and in cooling time,the symptoms has better effect than that of western medicine control group.2.Wormwood and Scutellaria Gallbladder Clearing Decoction treats dampness-heat syndrome with predominant heat to alleviate symptoms quickly; while it treats dampness-heat syndrome with predominant dampness,cooling time is fast,Prompt this medicine has effect to the two syndrome types.Symptoms and signs of patients continued a long time after the temperature dropping in dampness-heat syndrome with predominant dampness,which reflects the viscous characteristics of dampness.3.Oxidative stress in the patients of wet heat more emphasis on damp-heat syndrome of viral upper respiratory tract infection has certain difference,but the significance can not be determined,need to increase the sample size further observation.4.Wormwood and Scutellaria Gallbladder Clearing Decoction increases the role of capacity of anti-oxidative stress of the body,which compared to western medicine shows a certain degree of advantage,should increase the number of cases further observation.