Scoring Systems For Evaluating The Prognosis Of Severe Hepatitis And Theirs Clinical Application Status

Severe hepatitis is a clinical syndrome caused by multiple factors resulted to large hepatocytes necrosis. The main clinical manifestations are jaundice, coagulation dysfunction, ence- phalopathy, ascites, and so on. It is the most serious liver disease with sudden onset, rapid progress, bad curative effect, so many complications, high morbidity and mortality, poor prognosis, and low survival rate. Early diagnosis and intensive medical therapy is imperative and important. There are much more factors determine the prognosis of severe hepatitis through our research now, but the predictive value are different according to different causes, different pathogens, different individual, different status and different therapeusis. In addition, some of the clinical index is subjective. It is an observable hot issues that how to choose a more objective, more easier, more exact index used for clinical application in order to evaluate the prognosis of severe hepatitis.For the past few years,several mathematical models or scoring systems for evaluating the prognosis of severe hepatitis have established, and then the prognostic factors of severe hepatitis are analyzed in order to guide treatment. The Child-Turcotte-Pugh(CTP)score, Model for End-stage Liver Disease (MELD) including△MELD and MELD–Na, King′s College Hospital (KCH) criteria, the sequential organ failure assessment (SOFA) score, scoring model of severe viral hepatitis (SMSVH) , simple acute physiology scoreⅡ(SAPSⅡ) and acute physiology and chronic health evaluation (APACHEⅡ/Ⅲ) next will be reviewed, and their efficacy and significance for evaluating the prognosis of the severe hepatitis also will be analyzed in this review.