Early Evaluation Of HIE Combined Kidney Damage

Objective: To investigate the value of urine trace protein in early diagnosis and grading of the hypoxic ischemic encephalopathy(HIE)and early evaluation of HIE combined with renal injury.Methods:47 cases of full-term HIE neonate were tested of urineβ2-microglobulin (β2-M), microalbuminuria (MA) ,serum creatinine(Cr) and Urea nitrogen(BUN) within three days postnatal, each case's clinical grading was assessed in 7 days postnatal ,and 13 healthy neonate in the same period were randomly chosen as control group . Those index were observed and compared between test and control groups, correlation analysis was also carried out .Results: The urineβ2-M and MA in HIE group were significantly higher compared with control group in three days postnatal (P <0.01).With increase of clinical severity , urineβ2-M and MA gradually increased (P< 0.05).Urineβ2-M and MA in HIE group were positive correlated (r = 0.5804, P <0.05). The abnormal rate of urineβ2-M, MA was significant higher than serum Cr, BUN (P <0.05).Conclusions: on the base of clinical manifestation of asphyxiated newborns, measurement of urineβ2-M and MA in 3 days postnatal was valuable in early diagnosis and grading of HIE and early evaluation of the HIE combined with renal injury.