Study About The Effects Of Fuganling On Anti-hepatitis B Virus Within The Body Of Duck

Objective: To study the effects of Fuganling (FGL) in Anti- Duck Hepatitis B Virus(DHBV) . Methods: A total of 89 Beijing's one-day-old duck were used , they were divided into three group,every group ducks were given the DHBV -positive serum via intravenous injection to establish the model of duck Hepatitis B Virus and then they were randomly divided into 3 groups: the FGL group, control group and Lamivudine group. The duck of FGL group were given treatment of FGL orally at doses of 0.5 g/kg(low-dosage), 1.0 g/kg(middle-dosage), and 2.0g/kg (high-dosage), twice a day, for 10 days, then the blood of ducks were collected before medication, and at the 5th, 10th day after medication, and the 3th day after stope medication. The level of serum DHBV-DNA were detected, and the inhibition rates of duck serum DHBV-DNA were calculateted. The ducks of control group and Lamivudine group were given NS and Lamivudine.Results: The level of serum DHBV-DNA in FGL group with high-dosage decreased remarkably on the 5th, 10th day after medication, and the 3th day after stope medication, and the inhibition rates of duck serum DHBV-DNA increased significantly, Compared to the control group the difference was of Significance(P< 0.01); the level of serum DHBV-DNA in FGL group with middle -dosage decreased obviously on the 10th day after medication, and the 3th day after stope medication, the inhibition rates of duck serum DHBV-DNA increased obviously, there was significant difference Compared to the control group (P< 0.01), but there was no difference compared to Lamivudine group. The level of serum DHBV-DNA and the inhibition rates of duck serum DHBV-DNA had no obvious change in the different times in FGL group with low-dosage. Conclussion: FGL with high-dosage and middle-dosage had remarkably effect in anti- duck hepatitis B virus within duck body.