Clinical Significance Of CD61 And CD62p Variation In Kswasaki Disease

Objective:Through detecting the whole blood levels of CD61 and CD62p counts in acute stage and convalescence of Kawasaki disease, to study CD61,CD62p with Kawasaki disease and its complicated relationship between coronary artery lesions, and to further explore the pathogenesis of Kawasaki disease,treatment and early detection of coronary artery abnormalities from occurring.Methods:The positive expression rates of CD61 and CD62p in KD patients were measured by flow cytometry.Results:1.The whole blood levels of CD61 and CD62p in acute phase and convalescent phase of Kawasaki disease were higher than that in control group, both had statistical difference(P<0.05).2.In acute phase and convalescent phase of Kawasaki disease, the whole blood CD62p in patients with coronary artery lesion group were higher than that in non-coronary artery lesion group, had statistical difference (P＜0.01).3.Compared with the group in acute phase, the whole blood CD61 in patients had not significant difference in convalescent phase(P>0.05). There were not statistical difference between coronary artery lesion group and non-coronary artery lesion group (P>0.05).4.CD62p counts in acute phase and convalescent phase of Kawasaki disease were higher than that in control group, both had statistical difference (P<0.01); CD62p counts in acute phase were higher than convalescent phase (P<0.05).Conclusions:In the pathological course of immunity vasculitis in KD, the platelet activation participates. The treatment of aspirin and IVIG can inhabit the high expression of CD61 and CD62p,and can degrade the degree of the platelet activation. It is valuable in diagnosis and treatment effects judgment to have dynamic observation of the positive expression rates of CD62p,which is of high value in prediction of coronary artery abnormalities.