Expression Of CD147 And MMP-9 In Pancreatic Carcinoma And The Clinical Significance

ObjectiveTo study the expression of CD 147 and matrix metalloproteinase-9 (MMP-9) in Pancrea tic carcinoma and their relationship. Their relationships between the two factors and with clinicopathologic factors were analyzed.And discuss their clinical significance.MethodsThe expression of CD 147 and MMP-9 were detected by immunohistochemical technique in 60 cases of human Pancreatic carcinoma and 20 cases of non-tumor Pancreatic tissues.The relationships between their expression and the clinical pathological characteristic were analyzed statistically.Results1. The positive expression rates of CD 147 were 68.3%(41/60); respectively, showing a significant difference between Pancreatic carcinoma and normal non-tumor Pancreatic tissues adjacent to tumor (p<0.05). The expression of CD 147 was not correlated with age, gender, lymphatic metastasis and distant metastasis (p>0.05), but correlated with histological grade and TNM staging (p<0.05);2. The positive expression rates of MMP-9 were 65%(39/60); respectively, showing a significant difference between Pancreatic carcinoma and normal non-tumor Pancreatic tissues adjacent to tumor (p<0.05). The expression of MMP-9 was not correlated with age, gender and distant metastasis (p>0.05), but correlated with histological grade,TNM staging and lymphatic metastasis (p<0.05);3. In Pancreatic carcinoma, CD 147 expression intensity was correlated with MMP-9(p<0.05).ConclusionsThere are overexpressions of CD 147 and MMP-9 in Pancreatic carcinoma,the expression of CD 147 was correlated with histological grade and TNM staging;while MMP-9 was significantly correlated with histological grade,TNM staging and lymphatic metastasis. The expression of CD 147 was positive with MMP-9, the variation of their expressions may contribute to the pathogenesis, development andprognosis of Pancreatic carcinoma.