Clinical Observation Of Treatment Of Epilepsy By Antiepileptic Comprehensive Protocol Of Integrated Traditional And Western Medicine

Objective:Observe clinical effect of treatment of hospitalized patients with epileptic seizure in general hospital by antiepileptic comprehensive protocol of integrated traditional and western medicine(ITWMAECP) of Guangzhou university of chinese medicine first affiliated hospital neurology, and explore the methods of evaluation of the epileptic effect, treated by integrated traditional and western medicine.Method:This study was a randomized controlled clinical trial. there are 27 cases of subjects as a qualified, met the inclusion criteria of epilepsy, belonged to guangzhou university of chinese medicine first affiliated hospital of hospitalized epilepsy from August 2009 to April 2010. Randomly divided into control and treatment groups, then on the basis of the general treatment and cause of treatment, the control group was given anti-epilepsy medicine, the treatment group was given intravenous Xingnaojing, differential treatment of TCM and anti-epilepsy medicine. Observation of treatment was 11±3 days. Before and after treatment observed and recorded the number of seizures, clinical symptoms and signs, chinese medical symptoms information and quality of life by the table of clinical observation, epileptic symptoms questionnaire of TCM and 31-item quality of life in epilepsy (QOLIE-31). After, evaluated clinical efficacy of epilepsy by seizure frequency, symptoms factor scores of TCM in epilepsy and the difference between symptoms factor score of TCM in epilepsy before and after treatment. Results:In this clinical trial, there are 27 cases of subjects, in which there are 26 cases completed the treatment program. And control group have 13 cases, 14 cases of treatment group, remove 1 case. Compared two groups of age and gender, difference are not significant (P>0.05).After treatment, the number of seizures compared efficacy results, treatment group, markedly effective, efficient, effective slip, inefficient, and the total effective rate is 84.62%,15.38%,0%,0% and 100%; the control group, markedly effective, efficient, effective slip, inefficient, and the total effective rate is 30.77%,61.54%,7.69%,0% and 92.31%. The markedly effective rate of the treatment group are better than the control group, and after the Mann-Whitney U test, the differences are significant(P < 0.05). The total effective rate of the treatment group are also better than the control group, but the difference are not significant(P> 0.05).Epileptic Symptoms Factor (SF) distribution shows, wind syndrome(23 cases) share the most number of patients, phlegm syndrome(21 cases)and closed card (20 cases) share a number of cases, and then all subjects scores of Heart blood deficiency and Kidney-yang deficiency can not meet diagnostic criteria of symptoms factor. Comparison of SF scores result, after treated by ITWMAECP, two groups scores of each SF after treatment are all less than before treatment, the differences are significant(P< 0.05). Prompt after treatment, all scores of SF are significantly lower. Before treatment, Blockage syndrome scores of SF in the treatment group is less than the control group, difference is significant (P< 0.05).The difference value between epileptic syndrome factor scores before treatment and after treatment (SFD) compared results, after treatment SFD of Heat-syndrome, Blood Stasis syndrome, and Kidney Yin Deficiency syndrome in treatment group is greater than the control group. SFD of Blockage syndrome in the treatment group is less than the control group. All differences are significant (P< 0.05). Comparison between SFD of Wind syndrome, Phlegm syndrome, Heart blood deficiency, Spleen Qi Deficiency syndrome and Kidney-yang deficiency in the treatment group and in the control group, All differences are not significant (P> 0.05).QOLIE-31 with epilepsy in our hospital the completion of the survey show, all patients in the qualifying, have 8 cases of patients who have completed QOLIE-31, and have 19 cases of patients who have failed to complete QOLIE-31. Survey completion rate was 30%.The study found that the reasons for failure to complete the investigation as follows:mental retardation and can not fully understand the content scale, limb weakness and can not write, illiteracy, and so on.Conclusion:Epileptic Symptoms Factor distribution find, epilepsy attack by the evil reality(wind, phlegm, blockage)of the main, the evidence for the standard emergency, and then clinical studies have reported similar.Comparative efficacy of seizure frequency display, effect, that ITWMAECP control seizure frequency,is better than the control group. Comparative efficacy of Chinese Medicine Symptom complex score display, after ITWMAECP, all symptoms factor scores of two groups are significantly lower, In which Heat-syndrome, Blood Stasis syndrome, and Kidney Yin Deficiency syndrome in treatment group scored significantly lower than the control group. That explain that ITWMAECP can not only reduce the number of clinical seizures, but also in improving the Heat-syndrome, Blood Stasis syndrome, and Kidney Yin Deficiency syndrome has obvious advantages.The study also expores methods of ITWMAECP Evaluation in the treatment of epilepsy. In which, evaluation, of which efficacy of seizure frequency and Chinese Medicine Symptom complex score, have been well implemented.It have realized the purpose of evaluation of efficacy of Integrated traditional and western medicine. But the implementation of quality of life is not well. QOLIE-31 in the experiment is the world's authoritative evaluation of quality of life in epilepsy, mainly used in evaluation of quality of life in epilepsy. This study has investigated the applicability of QOLIE-31 in comprehensive hospital epilepsy. The results find the applicability of QOLIE-31 overall is unsatisfactory, mainly due to that the crowd characteristics being measured had be changed.