The Expression Of Maspin And Caspase-3,MVD And Their Relation In The Hepatocellular Carcinoma

Objective:We studied the expression of Maspin (mammary serpin) protein in HCC (hepatocellular carcinoma) and its relationship with the tumor pathological characteristics, and analyzed its association with Caspase-3(aspartate-specific cysteine protease 3) and MVD(microvessel density). And purpose to explore the relationship of Maspin and the biological behavior of HCC and to explore its action and relevant mechanisms in tumorigenesis and progression of HCC.Methods:50 liver tumors and paraneoplastic liver tissues were obtained from hepatocellular carcinoma patients after hepatectomy. Microvessel density(MVD) in HCC was labeled using anti-CD34 antibody. The expression levels of Maspin and Caspase-3,CD34 were detected by immunohistochemistry.Results:The expression of Maspin and Caspase-3 in HCC tissues was lower than the expression in paraneoplastic liver tissues. The expression of Maspin and Caspase-3 was related with the differentiation of hepatocellular and metastasis of HCC, metastasis and the lower differentiation , the lower expression. The expression of Maspin was positively correlated with the expression of Caspase-3. The MVD in HCC tissues was higher than that in paraneoplastic liver tissues. It was also related with the differentiation of hepatocellular and metastasis of HCC , metastasis and the lower differentiation , the more MVD. The expression of Maspin was negatively correlated with the expression of MVD.Conclusion:Maspin can suppress the tumorigenesis progression and invasion metastasis of HCC probably through adjusting the action of caspase and suppressing vascularization.