Expression Of Fascin-1 Protein And Matrix Metalloproteinase-1 In Laryngeal Squamous Cell Carcinoma

Objective:To study the expression of Fascin-1 and MMP-1 (matrix metalloproteinase-1) in laryngeal squamous cell carcinoma (LSCC) and adjacent tissues and their clinical significance.Methods:Using citric-SP-immunochemical technique,the expression of Fascin-1 and MMP-1 were studied in different regions of larynx squamous cell carcinoma including 40 cases laryngeal carcinoma and adjacent tissues which was 0.5,1.0 and normal tissue away from cancer.Results:The expression of Fascin-1 reduced in sequence of cancer tissue,at 0.5cm,1.0cm and normal tissue adjacent to carcinoma,which were 80.0%,27.5%,22.5%,4.0%, the results of comparison with two group indicate that,there was no significant difference in rate of addition (P> 0.008)with group of 1.0cm and 2.0 cm and the group of 0.5cm and 1.0cm.the other groups differences were statistically significant (P<0.008). the expression of MMP-1 degraded in sequence of cancer tissue,at 0.5cm,1.0cm and normal tissue adjacent to carcinoma,which were 85.0%,35.0%,17.5%,5.0%, results of comparison with two group indicate that,there was no significant difference in rate of addition (P> 0.008)with group of 1.0cm and normal tissue and the group of 0.5cm and 1.0cm.the other groups differences were statistically significant (P<0.008).the result same to expression of fascin-1.the expression of Fascin-1 protein in Laryngeal squamous cell carcinoma have a relationship with clinical stage of cancer, tumor location, tumor differentiation and lymph node metastasis,but not associated with age and gender. the expression of MMP-1 have a relationship with clinical stage of cancer, tumor location, tumor differentiation and lymph node metastasis, but not associated with age and gender.the expression of Fascin-1 and MMP-1 were positive correlation(P<0.001).Conclusion:Fascin-1 and MMP-1 maybe directly associated with the development of LSCC, which may play an important role in the process of invasion and metastasis of LSCC,United detection of Fascin-1 and MMP-1 may be an important biologica factor affecting the prognosis judgement of LSCC.